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Although no specific drugs have been approved for treating sarcopenia, protein supplements rich in branched\u2010chain amino acid (BCAA) have been reported to increase muscle mass and function in elderly individuals. Fermentation of salmon placenta protein is an effective approach to improve BCAA content compared to previous sarcopenia\u2010related protein supplements. Therefore, this study aimed to evaluate BCAA content through salmon placenta protein (Sal) fermented with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    <\/jats:styled-content>\n                    (F\u2010Sal), analyze the expression of muscle\u2010forming genes in C2C12 myoblasts in\u00a0vitro, measure the weight gain of quadriceps femoris and gastrocnemius muscle, measure the volume and thickness of gastrocnemius muscle, and measure the expression of biomarkers related to sarcopenia in quadriceps femoris and gastrocnemius muscle in a mouse model of sarcopenia. Here, we report for the first time that salmon placental extracts (Sal) fermented with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. cerevisiae<\/jats:italic>\n                    <\/jats:styled-content>\n                    (F\u2010Sal) exhibit drastically elevated levels of BCAA, including leucine, isoleucine, and valine, and ameliorated the conditions of sarcopenia in both in\u00a0vitro and in\u00a0vivo sarcopenia models. When the addition of Sal or F\u2010Sal to cultured C2C12 myoblasts with dexamethasone\u2010induced sarcopenia, the expression level of the muscle\u2010forming gene MyoD was significantly increased in F\u2010Sal compared to Sal (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and the expression level of the muscle\u2010degrading gene MuRF1 was significantly decreased in F\u2010Sal compared to Sal (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). In a mouse model of sarcopenia, oral administration of F\u2010Sal for 14\u2009days following dexamethasone treatment increased muscle weight and the expression of muscle\u2010forming genes while mitigating muscle loss and reducing the expression of muscle\u2010degrading genes in both the quadriceps femoris and gastrocnemius muscles. These findings provide a therapeutic basis for treating muscle weakness in patients with end\u2010stage disease as well as sarcopenia\u2010related muscle conditions in elderly by improving BCCA content with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. cerevisiae<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010fermented salmon placental protein (F\u2010Sal).\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71370","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:05:13Z","timestamp":1766999113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Saccharomyces cerevisiae<\/i>\n                    \u2010Fermented Salmon Placental Protein Inhibits Muscle Loss in a Mouse Model of Sarcopenia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5328-4487","authenticated-orcid":false,"given":"Jung\u2010Chang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5057-653X","authenticated-orcid":false,"given":"Tae\u2010Joong","family":"Lim","sequence":"additional","affiliation":[{"name":"Nature Pharm Corp  Gimpo\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3619-6053","authenticated-orcid":false,"given":"Hye\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5964-9859","authenticated-orcid":false,"given":"Sung\u2010Moon","family":"Jun","sequence":"additional","affiliation":[{"name":"Nature Pharm Corp  Gimpo\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-9258","authenticated-orcid":false,"given":"Kyung\u2010Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130302"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.40"},{"key":"e_1_2_11_4_1","first-page":"361","article-title":"Anti\u2010Inflammatory Effect of Human Placental Extract: A Biochemical Mechanistic Approach","volume":"14","author":"Banerjee K. 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