{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:54Z","timestamp":1789168314408,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007434","name":"Ag\u00eancia Nacional de Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["CE0112\u201004\u201065\u201005\u20100119"],"award-info":[{"award-number":["CE0112\u201004\u201065\u201005\u20100119"]}],"id":[{"id":"10.13039\/501100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    \u03b2\u20101,3\/1,6\u2010glucan is an immune\u2010modulating functional ingredient. To enhance solubility, \u03b2\u20101,3\/1,6\u2010glucan oligosaccharides were developed from polysaccharides through gamma\u2010irradiation. Nevertheless, whether their safety and efficacy profiles are different remains unclear. Our previous study identified 2000\u2009mg\/day as the maximum short\u2010term tolerable dose of\n                    <jats:italic>Ophiocordyceps dipterigena<\/jats:italic>\n                    BCC2073\u2010derived \u03b2\u20101,3\/1,6\u2010glucan oligosaccharides and polysaccharides. However, the long\u2010term safety of this dosage was unknown. This randomized, blinded, placebo\u2010controlled trial was conducted to evaluate their safety over 12\u2009weeks. Ninety\u2010six healthy participants were randomly assigned to receive 2000\u2009mg daily of either \u03b2\u2010glucans oligosaccharides, \u03b2\u2010glucans polysaccharides, or placebo capsules (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932 each group). Adverse symptoms, changes in body weight, defecation, hematological, and biochemical parameters, vital signs, and heart function were assessed using subject diaries, interviews, blood and urine tests, and electrocardiograms. No serious adverse events or changes in body weight, liver or renal function, complete blood counts, blood glucose levels, urinalysis, or electrocardiogram were observed in any of the groups. Notably, supplementation with \u03b2\u2010glucan oligosaccharides, but not polysaccharides, resulted in significant reductions in total cholesterol and LDL levels compared to the control group. Only the polysaccharides group had significant positive (easier defecation) and negative (constipation, loose stools) defecation\u2010related symptoms. The negative symptoms (found in 3%\u201319% of participants) were mild. These findings indicate that daily supplementation with 2000\u2009mg of \u03b2\u20101,3\/1,6\u2010glucan oligosaccharides or polysaccharides for 12\u2009weeks is safe in healthy individuals. The oligosaccharides demonstrated superior lipid\u2010lowering efficacy with fewer adverse events compared to the polysaccharides. Possible defecation\u2010related side effects of \u03b2\u20101,3\/1,6\u2010glucan polysaccharides should be considered.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Thai Clinical Trial Registry: TCTR20240622005\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71379","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:52:48Z","timestamp":1772959968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Safety and Lipid Control Efficacy of \u03b2\u20101,3\/1,6\u2010Glucan Oligosaccharides and Polysaccharides Derived From\n                    <i>Ophiocordyceps dipterigena<\/i>\n                    BCC 2073 in Healthy Volunteers"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-7354","authenticated-orcid":false,"given":"Numphung","family":"Rungraung","sequence":"first","affiliation":[{"name":"Institute of Nutrition Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-2033","authenticated-orcid":false,"given":"Niramol","family":"Muangpracha","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakkapong","family":"Phucharoenrak","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8857","authenticated-orcid":false,"given":"Wai","family":"Prathumpai","sequence":"additional","affiliation":[{"name":"Biocontrol Technology Research Team, Integrative Crop Biotechnology and Management Research Group National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-6295","authenticated-orcid":false,"given":"Dunyaporn","family":"Trachootham","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2009.03.016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2007.12.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20164032"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2137"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602607"},{"key":"e_1_2_11_7_1","unstructured":"European Food Safety Authority. n.d.\u201cNovel Food.\u201dLast reviewed date: 27 March 2025. 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