{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:05Z","timestamp":1789988525155,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The link between Vitamin D (Vit D) deficiency and sudden sensorineural hearing loss (SSNHL), especially regarding recurrence and age\u2010related disparities, remains unclear. Recurrence and age\u2010specific risks of SSNHL are under addressed, limiting preventive strategies. This study investigated if Vit D deficiency increases SSNHL onset and recurrence risks, with a focus on age\u2010specific associations. In this prospective cohort study, 80 adult SSNHL patients and 60 matched controls were enrolled. All patients received standard therapy. Baseline serum 25(OH)D was measured, Vit D deficiency or insufficient patients were randomized in a single\u2010blind manner to receive 3\u2010month Vit D supplementation. We monitored Vit D levels, hearing recovery (pure\u2010tone audiometry at 10\u2009days and 3\u2009months), recurrence, and associated symptoms. Vit D deficiency was more prevalent in SSNHL patients than controls (38.8% vs. 10.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000). Recurrent SSNHL patients had significantly lower Vit D levels (18.4\u2009\u00b1\u20094.1\u2009ng\/mL) than first\u2010onset patients (24.9\u2009\u00b1\u20099.7\u2009ng\/mL). The highest deficiency rate (60.0%) was in patients under 30\u2009years. Multivariate analysis identified audiometric subtype, not Vit D status, as an independent outcome predictor. Vit D supplementation did not significantly improve recovery rates (75.7% vs. 68.2%) or alleviate symptoms. Vit D deficiency is a significant, modifiable risk factor for SSNHL onset and recurrence, with the strongest association in patients under 30\u2009years old. However, short\u2010term Vit D supplementation initiated after SSNHL diagnosis failed to improve clinical outcomes, underscoring that long\u2010term maintenance of adequate Vit D levels, rather than acute post\u2010symptom intervention, may be critical for reducing SSNHL risk in high\u2010risk populations.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71383","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:27:23Z","timestamp":1768422443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D Deficiency as a Risk Factor for Onset and Recurrence of Sudden Sensorineural Hearing Loss: A Prospective Cohort Study With Age\u2010Specific Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-7025","authenticated-orcid":false,"given":"Qi","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Qinglan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shuowei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Mengshi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Qin","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Hospital, The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Hongyin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Juntao","sequence":"additional","affiliation":[{"name":"School of Medicine Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yunping","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Seventh Afffliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000004391"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2022.05.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/ep\u20102019\u20100193"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859885"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072097"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1390953"},{"issue":"6","key":"e_1_2_11_8_1","first-page":"443","article-title":"Guideline of Diagnosis and Treatment of Sudden Deafness (2015)","volume":"50","author":"Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; 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