{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:56:18Z","timestamp":1791568578009,"version":"4.3.4"},"reference-count":100,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluated the antioxidant and neuropharmacological potentials of methanol extract of\n                    <jats:italic>Oroxylum indicum<\/jats:italic>\n                    bark (MOIB) to advocate the scientific basis of its traditional use in medical folklore. The preliminary phytochemical screening and GC\u2013MS analysis identified twenty phytochemicals in MOIB. Besides, in EPM, MOIB exhibited an increase in time spent and the number of entries in open arms while an enhancement in head dipping was demonstrated by MOIB in HBT compared to control, indicating anxiolytic activities. Furthermore, a dose\u2010dependent reduction in locomotor activities together with immobility time was revealed by MOIB in the hole cross test, open field test, and tail suspension test, forced swimming test, respectively in comparison to that of control suggesting sedative and antidepressant activities. Again, the molecular docking analysis revealed two compounds CID 550198 and CID 10393 with a good binding affinity to all the targeted receptors together with promising pharmacokinetic and toxicity profiles evident from ADME\/T analysis. Consequently, the respective molecular dynamic simulation study confirmed the stability of the protein\u2010ligand complexes. Moreover, two compounds with CID 550198 and CID 10393 might be used as natural lead compounds for the treatment of anxiety, sleep disorders, and depression. Yet, advanced studies are required to reveal the fundamental mechanism of these activities.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71391","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:36:16Z","timestamp":1768383376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Oroxylum indicum<\/i>\n                    (L.) Bark Ameliorates Anxiety and Depression: Evidence From Experimental and Computational Studies"],"prefix":"10.1002","volume":"14","author":[{"given":"Md.","family":"Aktaruzzaman","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Organic Pharmacy and Medicinal Chemistry Laboratory, Department of Pharmacy Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Laboratory of Advanced Computational Biology, Biological Research on the Brain (BRB)  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Enamul Kabir","family":"Talukder","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trina","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Organic Pharmacy and Medicinal Chemistry Laboratory, Department of Pharmacy Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Asibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Organic Pharmacy and Medicinal Chemistry Laboratory, Department of Pharmacy Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Tarikul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Computational Biology, Biological Research on the Brain (BRB)  Jashore Bangladesh"},{"name":"Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannatul","family":"Ferdous","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jahangirnagar University  Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmul","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Science Gono Bishwabidyalay  Savar Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Saif","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas Ivan Nobre","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Pharmacology, Bioscience Center Federal University of Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Obayed","family":"Raihan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Chicago State University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Rehman","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Lahore University of Biological and Applied Sciences  Lahore Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bratati","family":"Sikdar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bose Institute, Unified Academic Campus  Salt Lake, Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore Kumar","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Organic Pharmacy and Medicinal Chemistry Laboratory, Department of Pharmacy Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.2005463117\/\u2010\/DCSUPPLEMENTAL"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOM10040561"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8040068"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-022-00770-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402250"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES26040975"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040975"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8877757"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12040383"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/853175"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5034827"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20100105.109404"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118695"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.31254\/phyto.2018.7212"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1562038"},{"issue":"3","key":"e_1_2_12_17_1","first-page":"272","article-title":"Novel Anticancerous Compounds From Sargassum Wightii: In Silico and In\u00a0Vitro Approaches to Test the Antiproliferative Efficacy","volume":"7","author":"Begum S. M. F. M.","year":"2017","journal-title":"Journal of Advanced Pharmacy Education & Research"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1846"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/BIB\/BBAA382"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.11.009"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","unstructured":"Bowers K. J. E.Chow H.Xu et\u00a0al.2006.\u201cScalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters. Proceedings of the 2006 ACM\/IEEE Conference on Supercomputing SC'06.\u201dhttps:\/\/doi.org\/10.1145\/1188455.1188544.","DOI":"10.1145\/1188455.1188544"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113884"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/876426"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c04468"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci300367a"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04895"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17629"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0694-82"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201062703\u2010658\u20100_11"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0975\u20103575(10)80121\u2010X"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/JM051256O"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.01.021"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113664"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACSCOMBSCI.0C00058\/ASSET\/IMAGES\/LARGE\/CO0C00058_0003.JPEG"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8853056"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120407"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JCTC.5B00864\/SUPPL_FILE\/CT5B00864_SI_001.ZIP"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/neuroglia5040027"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202404160"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401257"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1273408"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/BIB\/BBAA160"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534867"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.08.017"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101376963"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42074"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201098092\u2010y"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra05073h"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010024\u201001204\u20108"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FBIO.2021.100881"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/sinusitis5010009"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.07.006"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.07.004"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249253"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2016.601222"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102654\u20105"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1657"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2010.04.008"},{"key":"e_1_2_12_60_1","doi-asserted-by":"crossref","unstructured":"Leaves W. K. K.Sarkar T.Islam et\u00a0al.2021. \u201cTropical Journal of Natural Product Research Evaluation of Pharmacological Activities of Fractionated Extracts of Hoya Parasitica.\u201d5:1747\u20131754.","DOI":"10.26538\/tjnpr\/v5i10.9"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi500525s"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201471"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ADDR.2012.09.019"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10822\u2010013\u20109644\u20108"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2018.1458875"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SJBS.2022.103312"},{"key":"e_1_2_12_67_1","first-page":"87","volume-title":"Alien Powers","author":"Minogue K.","year":"2018"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010016\u20100684\u20107"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/JM00385A024"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3400"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836\u2010198106000\u201000009"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SJBS.2015.10.026"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9081449"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30040851"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JCTC.8B01026"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201086211\u20104"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3736\/jintegrmed2013025"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.110044"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/587807"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100651\u20107978"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11666131120230309"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201005621\u20100"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1331758"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.26538\/tjnpr\/v5i10.9"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27001"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596\u2010020\u201000463\u20105"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2020.112821"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2024.101486"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00213\u2010008\u20101232\u20106\/FIGURES\/5"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20103057(01)00660\u20108"},{"key":"e_1_2_12_92_1","first-page":"534","article-title":"Essential Oil Constituents and Antimicrobial Activity of the Seeds of Zanthoxylum Armatum Dc. From Chamoli, Uttrakhand","volume":"7","author":"Sultana S.","year":"2020","journal-title":"European Journal of Pharmaceutical and Medical Research"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1407331"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139924"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109103091"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2024.09.001"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020017n"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122138"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020435"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13394"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596\u2010016\u20100222\u20101"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:32:49Z","timestamp":1789986769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/fsn3.71391"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71391","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71391"}}