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Over centuries, traditional medical systems have relied on medicinal plants to alleviate gastrointestinal conditions, and current pharmacological research is beginning to validate these ancestral practices. Many plants contain a rich diversity of bioactive compounds, including polyphenols, flavonoids, terpenes, and alkaloids, that exert antioxidant, anti\u2010inflammatory, and anticancer effects, making them promising candidates for complementary therapy. This review compiles and critically analyzes data from the past decade on plant extracts and isolated natural compounds tested in\u00a0vitro, in\u00a0vivo, and ex\u00a0vivo for their protective effects on intestinal health. Evidence consistently indicates that plant\u2010derived molecules can suppress inflammatory mediators, modulate oxidative stress responses, restore epithelial barrier integrity, and induce apoptosis in neoplastic cells. 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