{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:31Z","timestamp":1789988551953,"version":"4.0.1"},"reference-count":152,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes. Emerging evidence highlights the therapeutic potential of plant\u2010derived essential oils and fatty acids in modulating neuroinflammatory pathways through multi\u2010target mechanisms. Essential oils enriched with terpenoids (e.g., carnosic acid, eugenol) attenuate microglial activation and cytokine production by suppressing NF\u2010\u03baB and MAPK signaling, while polyunsaturated fatty acids (PUFAs), particularly omega\u20103, enhance blood\u2013brain barrier integrity and promote the resolution of oxidative stress via Nrf2\u2010mediated antioxidant defenses. Preclinical studies demonstrate that these compounds reduce A\u03b2 plaque burden, protect dopaminergic neurons, and ameliorate cognitive deficits in animal models of AD and PD. This review provides a comprehensive evaluation of the multifaceted roles of essential oils and fatty acids in combating neuroinflammation and their potential as therapeutic agents. Furthermore, this sets a foundation for further research into translating these natural products into clinical applications in modulating neuroinflammation and related disorders.<\/jats:p>","DOI":"10.1002\/fsn3.71422","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:08:38Z","timestamp":1767949718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010Neuroinflammation Activity of Essential Oils and Fatty Acids"],"prefix":"10.1002","volume":"14","author":[{"given":"Zelong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yige","family":"Song","sequence":"additional","affiliation":[{"name":"Bao Feng Key Laboratory of Genetics and Metabolism  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Attia Ahmed","family":"Abdelmoaty","sequence":"additional","affiliation":[{"name":"Bao Feng Key Laboratory of Genetics and Metabolism  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiujun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Bao Feng Key Laboratory of Genetics and Metabolism  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.045"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.103813"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112230"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020408"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24939"},{"key":"e_1_2_12_7_1","article-title":"Aromatherapy for Dementia","volume":"8","author":"Ball E. 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