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Based on the theory of medicinal food harmony (MFH), 121 potential active components were identified from six foods, including\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Hovenia dulcis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , chicory, and umeboshi, by UPLC\u2010QTOF\u2010MS\/MS technology. HLB characteristic active components such as quercetin, catechin, and ferulic acid were verified through molecular docking. In\u00a0vivo experiments showed that HLB significantly reduced serum LPS, ALT, AST, TC, and TG levels, upregulated the expression of intestinal tight junction protein (ZO\u20101\/Occludin), and inhibited the activation of the TLR4 (Toll\u2010like receptor 4)\/NF\u2010\u03baB\/NLRP3 inflammatory axis in ALD model mice. Meanwhile, HLB restored the homeostasis of intestinal flora and the metabolism of short\u2010chain fatty acids (SCFAs), confirming that it synergistically ameliorated liver injury through the \u201cflora\u2010SCFAs\u2010intestinal barrier\u201d axis. This study reveals the molecular basis for the regulation of ALD by food\u2010based natural ingredients through liver \u2013 gut interactions and provides theoretical and practical basis for the development of functional beverages with both safety and multi\u2010target effects.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71435","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:58:03Z","timestamp":1767808683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism Study on the Regulation of Intestinal Microecology by Hangover Liver\u2010Protecting Beverage for the Treatment of Alcoholic Liver Disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Wen","family":"Cai","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Shandong University of Traditional Chinese Medicine  Jinan 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