{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:03:04Z","timestamp":1789988584458,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174269"],"award-info":[{"award-number":["82174269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["GZY\u2010KJS\u2010ZJ\u20102025\u2010035"],"award-info":[{"award-number":["GZY\u2010KJS\u2010ZJ\u20102025\u2010035"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Astragalus membranaceus<\/jats:italic>\n                    (Fisch.) Bunge (AM)\u2014\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    <\/jats:styled-content>\n                    Bunge (SM) decoction (ASD) is a herb pair not only widely used in clinic against cardiovascular diseases and metabolic syndrome, but also as key compositions in some functional foods. However, the pairing ratios and potential mechanisms of ASD in preventing metabolic syndrome are still unclear. The present study comprehensively evaluated how the pairing ratios of AM and SM affect the treatment of ASD against high\u2010fat diet (HFD)\u2010induced metabolic disorder and investigate the roles of gut microbiota in the biological process. To establish a metabolic syndrome model, thirty SD male rats received a 10\u2010week HFD. All rats were divided into six groups randomly: ND, HFD, ASD\u2010A (the quality ratio of 1:2\u2009AM to SM), ASD\u2010B (the quality ratio of 1:1\u2009AM to SM), ASD\u2010C (the quality ratio of 2:1\u2009AM to SM), and Simvastatin groups, and treated with corresponding medicine or saline. Biochemical changes and inflammation levels in serum and liver were assessed, while histopathology staining was conducted to evaluate liver and intestinal barrier lesions. Moreover, 16S rRNA sequencing technology was employed to assess the gut microbiota structure, and a targeted metabolomics method was utilized to quantify the fecal content of BAs and SCFAs. Administration of ASDs in three different pairing ratios considerably alleviated obesity, hyperlipidemia, systemic inflammation, liver injury, and intestinal barrier disorder in rats. Among the three decoctions, ASD\u2010A showed the greatest potential in multi\u2010aspects. Furthermore, ASD\u2010A significantly ameliorated gut microbiota dysbiosis and the imbalance of SCFAs and BAs induced by HFD. Especially, correlation analysis results suggested that the levels of lactic acid, 3\u2010hydroxybutyric acid, and 3\u2010hydroxypropionic acid are potential therapeutic biomarkers. The research findings indicated that ASDs could effectively prevent HFD\u2010induced metabolic syndrome, among which ASD\u2010A, with a quality ratio of 1:2 (AM: SM) exhibited superior effects. ASD\u2010A also significantly ameliorated gut microbiota disorders induced by HFD and promoted the production of beneficial metabolites.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71436","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:01:52Z","timestamp":1767949312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Astragalus membranaceus<\/i>\n                    \u2014\n                    <i>Salvia miltiorrhiza<\/i>\n                    Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High\u2010Fat Diet: A Comparative Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Haiyin","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Chinese Medicine for Cardiovascular and Cerebrovascular Disease  Hangzhou 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