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This situation demands natural and healthy therapeutic diets. Rice bran is a widely available, nutrient\u2010dense by\u2010product of rice. This study aimed to explore the compositional profile of optimized solid\u2010phase fermented rice bran (FRB) and nonfermented rice bran (NFRB) and, subsequently, its effect on HFD\u2010induced obese rats. We found that the fermentation process improved the nutritional quality and antioxidant properties of rice bran, and FRB supplementation (8\u2009weeks) decreased body weight gain by 3.5%, blood glucose levels by 2.03\u2009mmol\/L, and liver fat. However, FRB administration improved cognitive function, while the improvement in lipid profile was associated with the downregulation of hepatic genes (G6PC, FASN, and HMGCR) expression. Additionally, liver tissue staining suggests that FRB supplementation can improve liver morphology by reducing sinusoidal dilation, fat accumulation, and necrosis. Our results demonstrate that FRB could be effectively used to treat and prevent lifestyle\u2010related diseases.<\/jats:p>","DOI":"10.1002\/fsn3.71439","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:31:03Z","timestamp":1768026663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fermented Rice Bran: A Promising Therapeutic Agent Against High\u2010Fat Diet\u2010Induced Metabolic Disorders"],"prefix":"10.1002","volume":"14","author":[{"given":"Afroza","family":"Sultana","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Technology Jashore University of Science and Technology  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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