{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:24:26Z","timestamp":1792729466459,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503257"],"award-info":[{"award-number":["81503257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to develop an oral solid dispersion nutrient delivery system of resveratrol (RSV) and Eudragit E PO (E PO) for the prevention of rheumatoid arthritis. The RSV\u2010E PO solid dispersion, prepared by the solvent method at a drug\u2014polymer ratio of 1:7 (w\/w), turned resveratrol into an amorphous state, as proved by SEM, DSC, XRD, and FTIR. Over 80% of resveratrol was released in\u00a0vitro, a 13\u2010fold increase compared to raw resveratrol. In male Sprague\u2014Dawley rats, its oral administration (20\u2009mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) doubled bioavailability versus unformulated resveratrol. Evaluated in an adjuvant\u2010induced arthritis (AIA) model, the compound demonstrated significant anti\u2010arthritic effects. These protective effects were primarily mediated through the modulation of key inflammatory and oxidative stress pathways, as evidenced by a marked reduction in pro\u2010inflammatory cytokines (IL\u20106, TNF\u2010\u03b1, IL\u20101\u03b2) and malondialdehyde (MDA) levels, coupled with an increase in the anti\u2010inflammatory cytokine IL\u201010 and the antioxidant enzyme superoxide dismutase (SOD). Also, its safety was confirmed by stable AST, ALT, CREA, and BUN levels. In summary, the RSV\u2010E PO solid dispersion, with better dissolution and bioavailability, serves as an effective oral nutrient delivery system for RSV.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71464","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:51:54Z","timestamp":1770238314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Bioavailability Resveratrol Delivery System: A Novel Nutritional Strategy for the Prevention and Alleviation of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"14","author":[{"given":"Chenchen","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian China"},{"name":"School of Life and Health Dalian University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0812-9576","authenticated-orcid":false,"given":"Chungang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Liaoning University of Traditional Chinese Medicine  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104985"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2024.100887"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120206"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01525\u20108"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020737"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113022"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113141"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104939"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5c00303"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.10.051"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010018\u20104080\u20108"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.06.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2015.10.030"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040880"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2017.11.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.033340"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2024.100259"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.106563"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.10.024"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010015\u20100962\u20103"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121925"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10152"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.12.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.05.025"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b05047"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2022.68.6.28"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118447"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.11.048"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.04.022"}],"container-title":["Food Science &amp; 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