{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:03:09Z","timestamp":1789988589463,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS\u20102023\u201000208776"],"award-info":[{"award-number":["RS\u20102023\u201000208776"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS\u20102023\u201000221563"],"award-info":[{"award-number":["RS\u20102023\u201000221563"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prolonged high\u2010fat and high\u2010sucrose diets (HFHS) diet accelerates skeletal muscle atrophy and impairs muscle function. Combined HFHS diet and dexamethasone (Dex), a synthetic glucocorticoid which involves the induction of protein degradation, will promote atrophy of skeletal muscle. Although we previously demonstrated that peanut sprout extract (PSE) inhibits adipogenesis, its impact on HFHS+Dex\u2010induced muscle atrophy remained unknown. To investigate, we treated C57BL\/6 male mice with a control or HFHS diet, with or without PSE (10\u2009mg\/kg BW), over 10\u2009weeks, introducing Dex (10\u2009mg\/kg BW) once daily for six consecutive days to induce muscle atrophy. PSE treatment reduced skeletal muscle triglyceride accumulation, restored muscle strength (grip and hanging capacity), and mitigated muscle atrophy expression. While systemic interleukin (IL)\u20101\u03b2 levels were unaffected, PSE reduced inflammatory gene expression and inhibited nuclear factor\u2010\u03baB (NF\u2010\u03baB) protein expression in skeletal muscle, enhanced mitochondrial function (increased mitochondrial transcription factor A (TFAM), oxidative phosphorylation (OXPHOS) complex IV\/V protein expression, but no differences in peroxisome proliferator\u2010activated receptor gamma coactivator 1\u2010alpha (PGC1\u03b1)). Consistent with these results, PSE protected against muscle atrophy in Dex\u2010treated C2C12 cells by modulating atrophic and inflammatory expression. This study highlights PSE's efficacy in attenuating skeletal muscle atrophy and mitigating inflammation with partial enhancement of mitochondrial function.<\/jats:p>","DOI":"10.1002\/fsn3.71469","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:11:47Z","timestamp":1768893107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitigating Dexamethasone\u2010Induced Muscle Wasting and Mitochondrial Impairment in Mice on a High\u2010Fat and High\u2010Sucrose Diet With Peanut Sprout Extract"],"prefix":"10.1002","volume":"14","author":[{"given":"Sang\u2010Mi","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi My Tien","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Jeju National University  Jeju Korea"},{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"OLAOLAB Inc  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhae","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Jeju National University  Jeju Korea"},{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University  Jeju Korea"},{"name":"Center for Nutrition\u2010Disease Research &amp; Intervention Systems Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9047821"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2022.105808"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90225-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz034"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.04.019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00234.2014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(64)90050-4"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"199","article-title":"Mitochondrial Transcription Factor A Is a Proinflammatory Mediator in Hemorrhagic Shock","volume":"30","author":"Chaung W. W.","year":"2012","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04369-z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.2.142"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01244.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13270"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0074-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00013.2019"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9915-y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf053169a"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031111"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1214"},{"key":"e_1_2_12_22_1","first-page":"10","article-title":"Obesity Augments Glucocorticoid\u2010Dependent Muscle Atrophy in Male C57BL\/6J Mice","volume":"8","author":"Gunder L. C.","year":"2020","journal-title":"Biomedicine"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000134364.61406.26"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01026.2004"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.18427"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12434"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092163"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.11.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13583"},{"key":"e_1_2_12_30_1","first-page":"9","article-title":"Inflammation: Roles in Skeletal Muscle Atrophy","volume":"11","author":"Ji Y.","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13207"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.3.160"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102419"},{"key":"e_1_2_12_34_1","first-page":"5","article-title":"Nutrients Against Glucocorticoid\u2010Induced Muscle Atrophy","volume":"11","author":"Lee M. K.","year":"2022","journal-title":"Food"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235907"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0373-8"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2014.04.003"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b22-00171"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-3-9"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.06.014"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.02.012"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.007"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7578"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-021-00263-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1701200120"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01054"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03662-0"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2011.606928"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.19213"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.036"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.4.262"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2014.19.1.001"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051216"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00342A"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787846578"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12393"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0490"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190173"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13161"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150611126"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.07.018"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14133"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42323"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105979"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101185"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf048804b"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf200776w"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174995"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051255"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:34:43Z","timestamp":1789986883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/fsn3.71469"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71469","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71469"}}