{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:27:46Z","timestamp":1790767666044,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metabolic dysfunction\u2010associated steatotic liver disease (MASLD), formerly known as non\u2010alcoholic fatty liver disease (NAFLD), has emerged as the most prevalent chronic liver disorder in China, posing a significant threat to public health. While current Western pharmacological therapies demonstrate efficacy, they don't comprehensively ameliorate pathological components of MASLD and are often associated with substantial adverse effects. Saikosaponins (SSs), as the main active components of\n                    <jats:italic>Bupleurum chinense<\/jats:italic>\n                    , a traditional Chinese medicine (TCM), have been demonstrated to exert potential therapeutic effects on MASLD in recent years. However, there is a lack of systematic integration of their mechanisms of action and clinical evidence. This review aims to summarize the molecular mechanisms, clinical research progress, and existing challenges regarding the regulation of MASLD by SSs and systematically reviews the multiple therapeutic mechanisms of SSs, including the regulation of lipid metabolism, improvement of insulin resistance, exertion of anti\u2010inflammatory and antioxidant effects, modulation of intestinal flora, and inhibition of fibrosis, while summarizing the clinical applications of its compound formulas. Additionally, this article summarizes the cross\u2010organ protective effects of SSs in the liver, cardiovascular system, kidneys, immune system, and central nervous system, providing further theoretical references for the treatment of MASLD and its complications.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71470","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:14:30Z","timestamp":1770610470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Potential of Saikosaponins in\n                    <scp>MASLD<\/scp>\n                    and Cross\u2010Organ Protection: A Research Update"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3234-572X","authenticated-orcid":false,"given":"Jiayao","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0573-3022","authenticated-orcid":false,"given":"Ze","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i20.4688"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2015.1078461"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2023.101506"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709\u2010019\u201001411\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.04.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2017_405"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111383"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"320","article-title":"Mechanism of Action of Chaihu Shugan San in Treating Type 2 Diabetes Mellitus, Non\u2010Alcoholic Fatty Liver Disease, and Depression Through the Same Method","volume":"46","author":"Chang S.","year":"2023","journal-title":"Journal of Southwest Medical University"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.08.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058738420950593"},{"issue":"8","key":"e_1_2_11_14_1","first-page":"15","article-title":"Effect of Saikosaponin D on mRNA Expression of TGF\u03b2\u2010Smad Signaling Pathway in Rat Hepatic Stellate Cells","volume":"35","author":"Chen Y. R.","year":"2022","journal-title":"West China Journal of Traditional Chinese Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103230"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"106","article-title":"Bioinformatics Analysis of the Molecular Mechanism of Action of Saikosaponin A in the Treatment of Hyperlipidemia","volume":"39","author":"Cheng Y. P.","year":"2023","journal-title":"Journal of Guangdong Pharmaceutical University"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8070229"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010021\u201000469\u20104"},{"issue":"10","key":"e_1_2_11_19_1","first-page":"1049","article-title":"Insulin Resistance and Neurodegeneration: Roles of Obesity, Type 2 Diabetes Mellitus and Non\u2010Alcoholic Steatohepatitis","volume":"10","author":"Monte S. M.","year":"2009","journal-title":"Current Opinion in Investigational Drugs"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i40.6141"},{"issue":"8","key":"e_1_2_11_21_1","first-page":"69","article-title":"Mechanism of Action of Saikosaponin A in Intervening Hyperlipidemic Rats via the LKB1\u2010AMPK Signaling Pathway","volume":"35","author":"Du H. Y.","year":"2022","journal-title":"Journal of Traditional Chinese Medicine Research"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010020\u201010094\u20102"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00174"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.209973"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11155"},{"issue":"6","key":"e_1_2_11_27_1","first-page":"807","article-title":"Protective Effect of Saikosaponin a on Hepatic Steatosis in Rats With Non\u2010Alcoholic Fatty Liver Disease (NAFLD) Through Modulation of PPAR\u03b1 Signaling Pathway","volume":"24","author":"Gu X. X.","year":"2021","journal-title":"Journal of Practical Hepatology"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154219"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.11.011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.026"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155931"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674\u20108115.2020.03.005"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000373"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023040"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.19539\/j.cnki.2095\u20102694.2022.03.010"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24132365"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003141"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01795"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.15887\/j.cnki.13\u20101389\/r.2019.11.041"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154766"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.04.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01701\u20103"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00178"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506930"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001191"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.10.025"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.008"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010024\u201000747\u20109"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c23\u201000782"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121844"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.01.022"},{"issue":"14","key":"e_1_2_11_52_1","first-page":"2213","article-title":"Clinical Observation of Xiaoyao San Combined With Simvastatin in the Treatment of Non\u2010Alcoholic Fatty Liver Disease","volume":"34","author":"Li W.","year":"2019","journal-title":"Journal of Guangming Traditional Chinese Medicine"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.018"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.174"},{"issue":"15","key":"e_1_2_11_55_1","first-page":"28","article-title":"Regulatory Effect of Chaihu Shugan San Combined With Ferulic Acid on BDNF\/TrkB Signaling Pathway and Monoamine Neurotransmitters in the Prefrontal Cortex of CUMS Model Rats","volume":"31","author":"Li Y. X.","year":"2025","journal-title":"Journal of Experimental Traditional Chinese Medicine Formulas"},{"issue":"16","key":"e_1_2_11_56_1","first-page":"2346","article-title":"Clinical Observation on Modified Xiaochaihu Decoction in Treating Nonalcoholic Fatty Liver Disease","volume":"32","author":"Li Z.","year":"2017","journal-title":"Bright Chinese Medicine"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.11569\/wcjd.v24.i8.1159"},{"issue":"4","key":"e_1_2_11_58_1","first-page":"928","article-title":"Effect of Saikosaponin A Regulating PI3K\/Akt Signaling Pathway on Insulin Resistance in Type 2 Diabetic Mice","volume":"44","author":"Lin Y. L.","year":"2024","journal-title":"Journal of Gerontology of China"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.09.012"},{"issue":"15","key":"e_1_2_11_60_1","first-page":"6956","article-title":"Saikosaponin A Mitigates the Progression of Parkinson's Disease via Attenuating Microglial Neuroinflammation Through TLR4\/MyD88\/NF\u2010\u03baB Pathway","volume":"27","author":"Liu X. L.","year":"2023","journal-title":"European Review of Medical and Pharmacological Sciences"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.06.010"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.06.020"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176102"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061913"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4511"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.13194\/j.issn.1673\u2010842X.2025.06.020"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.009"},{"key":"e_1_2_11_68_1","volume-title":"Pharmacopoeia of the People's Republic of China: Part 1 (2020\u5e74)","author":"National Pharmacopoeia Commission","year":"2020"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133649"},{"issue":"4","key":"e_1_2_11_70_1","first-page":"101","article-title":"Efficacy of Xiaoyao San Combined With Diaozhi Fang in the Treatment of Non\u2010Alcoholic Fatty Liver Disease (Liver\u2010Spleen Deficiency Syndrome) and Its Effect on Serum LPS, LEP, and NSF\u20101 Levels","volume":"40","author":"Qiao H. X.","year":"2022","journal-title":"Sichuan Journal of Traditional Chinese Medicine"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108278(20)30805\u20109"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00623"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010023\u201000954\u20104"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00203\u20105"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16643"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010024\u201002180\u20108"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.70000"},{"issue":"6","key":"e_1_2_11_79_1","first-page":"692","article-title":"Clinical Efficacy Observation of Silibinin Capsules Combined With Xiaochaihu Tang in the Treatment of Non\u2010Alcoholic Fatty Liver Disease (NAFLD)","volume":"35","author":"Shi H. J.","year":"2019","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20251097"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8749564"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"issue":"7","key":"e_1_2_11_83_1","first-page":"1460","article-title":"Research Progress on In\u00a0Vivo Metabolic Pathways and Metabolites of Saikosaponin Compounds","volume":"42","author":"Song D. P.","year":"2019","journal-title":"Journal of Pharmaceutical Evaluation and Research"},{"issue":"7","key":"e_1_2_11_84_1","first-page":"1425","article-title":"Effect of Saikosaponin D on Insulin Resistance and FoxO1\/PGC\u20101\u03b1 Signaling Pathway in Type 2 Diabetic Rats","volume":"39","author":"Song P.","year":"2023","journal-title":"Journal of Immunology Research"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.021"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106181"},{"issue":"9","key":"e_1_2_11_87_1","first-page":"8","article-title":"Therapeutic Effect of Chaihu Shugan San on Patients With Non\u2010Alcoholic Fatty Liver Disease (NAFLD) of Liver Qi Stagnation Syndrome","volume":"21","author":"Su W.","year":"2021","journal-title":"Journal of Practical Integrated Traditional Chinese and Western Medicine"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.04.006"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.30286"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000501\u20109"},{"issue":"11","key":"e_1_2_11_92_1","first-page":"133","article-title":"Clinical Efficacy Observation of Modified Xiaochaihu Tang in the Treatment of Non\u2010Alcoholic Fatty Liver Disease (NAFLD)","volume":"13","author":"Tong S. W.","year":"2017","journal-title":"Journal of Traditional Chinese Medicine in Asia\u2010Pacific"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101370"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.53024"},{"issue":"2","key":"e_1_2_11_95_1","first-page":"295","article-title":"Correlation Between Non\u2010Alcoholic Fatty Liver Disease and Coronary Heart Disease","volume":"44","author":"Wang B.","year":"2023","journal-title":"Journal of Jilin Medical University"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311207"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.09.047"},{"issue":"2","key":"e_1_2_11_98_1","first-page":"84","article-title":"Study on the Reversal of Drug Resistance of Saikosaponin D in Paclitaxel\u2010Resistant Breast Cancer Cells","volume":"37","author":"Wang S. E.","year":"2024","journal-title":"Journal of Traditional Chinese Medicine Research"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7927"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106081"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.103910"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010023\u201002060\u20109"},{"issue":"3","key":"e_1_2_11_103_1","first-page":"129","article-title":"Clinical Efficacy of Chaihu Shugan San on Patients With Non\u2010Alcoholic Fatty Liver Disease (NAFLD) of Liver\u2010Spleen Deficiency Syndrome and Its Effect on Gut Microbiota","volume":"27","author":"Xie W. N.","year":"2021","journal-title":"Chinese Journal of Experimental Traditional Chinese Medicine Formulas"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1734"},{"issue":"23","key":"e_1_2_11_105_1","first-page":"3817","article-title":"Exploration of the Application Value of Chaihu Shugan San in Patients With Alcoholic Fatty Liver Disease","volume":"32","author":"Xuan X. M.","year":"2019","journal-title":"Medical Theory and Practice"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.033"},{"issue":"8","key":"e_1_2_11_107_1","first-page":"128","article-title":"Effect of Saikosaponin Combined With PD\u20101\/PD\u2010L1 Inhibitors on Proliferation, Migration, Invasion, and PI3K\/AKT Signaling Pathway in Gastric Cancer Cells","volume":"57","author":"Yang C.","year":"2025","journal-title":"Journal of New Traditional Chinese Medicine"},{"key":"e_1_2_11_108_1","unstructured":"Yaxin Z. W.Yanli H.Shuixiang et\u00a0al.2011.\u201cEffects of Saikosaponins\u2010D on STAT3 and COX\u20102 Signal Transduction Pathway in Experimental Hepatocarcinoma of Rats.\u201d"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1262433"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010022\u201001659\u20101"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01039"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.11.005"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14259"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001206"},{"issue":"4","key":"e_1_2_11_118_1","first-page":"6472","article-title":"Saikosaponin\u2010D Protects Renal Tubular Epithelial Cell Against High Glucose Induced Injury Through Modulation of SIRT3","volume":"8","author":"Zhao L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.12.030"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116110"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1992448"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.988"},{"issue":"15","key":"e_1_2_11_123_1","first-page":"56","article-title":"Clinical Study on Chaihu Shugan Powder in the Treatment of Non\u2010Alcoholic Fatty Liver Disease","volume":"28","author":"Zhu N.","year":"2018","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"19","key":"e_1_2_11_124_1","first-page":"4717","article-title":"Effect of Saikosaponin D on Glycolytic Metabolism and YAP1\/c\u2010Myc Expression in Gastric Cancer Cells","volume":"44","author":"Zhu Y. Q.","year":"2024","journal-title":"Journal of Gerontology of China"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030324"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2022.738088"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71470","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:25:28Z","timestamp":1790688328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":125,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/fsn3.71470"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71470","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71470"}}