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They are rich in dietary fiber, high\u2010quality proteins, mono\u2010 and polyunsaturated fatty acids, omega\u20103 fatty acids, vitamins (E, C, and K), and minerals such as magnesium, zinc, potassium, and iron. Bioactive compounds like polyphenols, carotenoids, and peptides contribute to their strong antioxidant and anti\u2010inflammatory effects, helping to mitigate oxidative stress and inflammation linked to chronic diseases. This review focuses on pumpkin, flax, sesame, chia, and melon seeds, valuable sources of essential micronutrients and bioactives with demonstrated nutraceutical potential. Pumpkin seeds enhance immune strength because of their mineral profile, whereas chia seeds provide omega\u20103 fatty acids associated with neuroprotection and anti\u2010Alzheimer's effects. The omega\u20103 content of flax and chia seeds offers cardioprotective benefits, whereas sesame lignans (sesamin) exhibit lipid\u2010lowering and anti\u2010aging properties. Flaxseed's secoisolariciresinol diglycoside (SDG) contributes to cardiovascular and anti\u2010cancer effects, and melon seed squalene supports immune health and exerts anti\u2010cancer activity. Mechanistic studies highlight these seeds' ability to regulate molecular pathways related to oxidative stress, inflammation, hypertension, diabetes, cancer, and metabolic disorders. Their bioactive constituents act through antioxidant, anti\u2010inflammatory, and metabolic\u2010regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in\u00a0vitro findings. Overall, pumpkin, flax, sesame, chia, and melon seeds demonstrate significant potential as natural sources of nutrients and bioactive compounds that promote cardiovascular, metabolic, and immune health. Their integration into daily diets and functional food formulations could play a vital role in preventing lifestyle\u2010related chronic diseases and enhancing overall well\u2010being.<\/jats:p>","DOI":"10.1002\/fsn3.71480","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:26:45Z","timestamp":1769668005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights"],"prefix":"10.1002","volume":"14","author":[{"given":"Nighat","family":"Raza","sequence":"first","affiliation":[{"name":"Deparment of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Sadaf","sequence":"additional","affiliation":[{"name":"Deparment of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeha","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Dietetics and Nutrition Lahore General Hospital  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza Abid","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection Muhammad Nawaz Shareef University of Agriculture  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqman","family":"Amrao","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-5924","authenticated-orcid":false,"given":"Fakhar","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University  Faisalabad Pakistan"},{"name":"Department of Food Science and Technology Nur International University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-9075","authenticated-orcid":false,"given":"Muhammad","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2821-5423","authenticated-orcid":false,"given":"Mohd Asif","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Agriculture Economics Kardan University  Kabul Afghanistan"},{"name":"Division of Research and Development Lovely Professional University  Phagwara Punjab India"},{"name":"University Centre for Research and Development Chandigarh University  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6163753"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.57239\/PJLSS\u20102024\u201022.1.00330"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010022\u201003793\u2010w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.54393\/pjhs.v6i4.2913"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40538\u2010021\u201000215\u2010w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12730"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.817808"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3989\/gya.0796161"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040883"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.14710\/jnc.v3i4.6844"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.25258\/ijpqa.14.1.40"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJFS2020.2015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.10.107"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.22038\/jctm.2021.55557.1315"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110985"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210902162120"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103209"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11111394"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.806566"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1392288"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2022.09.009"},{"key":"e_1_2_8_23_1","unstructured":"Bhardwaj S. 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