{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:02:44Z","timestamp":1792062164709,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alcoholic liver disease (ALD) is one of the leading causes of preventable liver\u2010related morbidity and mortality globally. Bioactive polysaccharides exhibit substantial potential as functional foods and therapeutic agents for the prevention and treatment of alcoholic liver injury (ALI).\n                    <jats:italic>Morchella<\/jats:italic>\n                    , an edible and medicinal fungus, contains polysaccharides with diverse biological activities. This study aimed to evaluate the protective effects of\n                    <jats:italic>Morchella<\/jats:italic>\n                    mycelium polysaccharides (MP) against alcohol\u2010induced liver injury and elucidate the underlying mechanisms. The MP was isolated from the\n                    <jats:italic>Morchella<\/jats:italic>\n                    mycelium using water extraction\u2013ethanol precipitation. Its primary component was glucose (96.555%), with a weight\u2010average molecular weight of 5.7\u2009kDa and an \u03b1\u2010glycosidic configuration. These characteristics indicated a highly homogeneous polysaccharide structure. Research findings demonstrated that the MP significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, improved lipid metabolism (evidenced by decreased triglyceride and cholesterol levels), and restored the histopathological structure of the mouse liver. Mechanistically, the MP alleviated oxidative stress by enhancing the activity of antioxidant enzymes (superoxide dismutase, catalase, and glutathione) and inhibiting lipid peroxidation (indicated by reduced malondialdehyde levels). Transcriptomic analysis further revealed the anti\u2010inflammatory mechanism of MP. It downregulated the expression of\n                    <jats:italic>Ifi16<\/jats:italic>\n                    ,\n                    <jats:italic>Pycard<\/jats:italic>\n                    , and\n                    <jats:italic>Nlrp3<\/jats:italic>\n                    by suppressing the Nlrp3 inflammasome in the NOD\u2010like receptor signaling pathway. This suppression subsequently inhibited\n                    <jats:italic>pro\u2010Casp1<\/jats:italic>\n                    activation and the pyroptosis of hepatocytes. Additionally, the MP upregulated the antimicrobial peptide\n                    <jats:italic>Camp<\/jats:italic>\n                    , highlighting its dual functions in anti\u2010inflammation and intestinal barrier protection. Collectively, these results suggest that\n                    <jats:italic>Morchella<\/jats:italic>\n                    mycelia polysaccharide, as a potent natural compound, holds significant promise for combating alcohol\u2010induced liver injury.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71483","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:06:13Z","timestamp":1769173573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatoprotective Effect of\n                    <i>Morchella<\/i>\n                    Mycelia Polysaccharides on Alcoholic Liver Injury and Its Mechanism Involving the Modulation of\n                    <scp>NOD<\/scp>\n                    \u2010Like Receptor Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5477-5740","authenticated-orcid":false,"given":"Xinyu","family":"Hu","sequence":"first","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghu","family":"Duan","sequence":"additional","affiliation":[{"name":"Xinyang City Academy of Agricultural Sciences  Xinyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leran","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Henan Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Zhai","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences; Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture and Rural Affairs, P. 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China; National Engineering Research Center of Edible Fungi; National R&amp;D Center for Edible Fungi Processing; Key Laboratory of Agricultural Genetics and Breeding of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biology and Food Engineering Huanghuai University  Zhumadian 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