{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:30:29Z","timestamp":1791653429071,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the neuropharmacological and analgesic effects of the methanol extract of\n                    <jats:italic>Macaranga peltata<\/jats:italic>\n                    leaves (MEMPL) in rodents, supported by computational modeling. Phytochemical and GC\u2013MS analyses revealed alkaloids, flavonoids, phenols, glycosides, diterpenes, and other bioactive compounds. MEMPL (200 and 400\u2009mg\/kg) significantly increased open\u2010arm exploration in the elevated plus maze and reduced head dipping in the hole\u2010board test (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), indicating anxiolytic activity. Dose\u2010dependent reductions in locomotor activity in the open\u2010field and hole\u2010cross tests (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) suggested central nervous system depressant effects. Although MEMPL reduced immobility in both FST and TST, its effects were notably weaker than fluoxetine, indicating modest antidepressant\u2010like activity. MEMPL also demonstrated significant antinociceptive effects in acetic acid\u2013induced writhing and formalin\u2010induced paw\u2010licking tests, likely via prostaglandin inhibition. Computational screening identified 2\u2010hydroxy\u20106\u2010methylbenzaldehyde as a potential bioactive compound with strong binding to proteins involved in anxiety, depression, and nociception. Overall, these findings highlight MEMPL's broad neuropharmacological and analgesic potential, demanding further mechanistic and dose\u2013response studies.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71484","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:36:42Z","timestamp":1769236602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Macaranga peltata<\/i>\n                    Alleviates Neuropsychiatric Disorders in Mouse Model and Computational Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Shaifullah Mansur","family":"Tanzil","sequence":"first","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Azizul","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Tasaffiul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Tanvir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israt","family":"Jahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arafat","family":"Faraque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mohammed","family":"Tareq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-6345","authenticated-orcid":false,"given":"Md Areeful","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-1635","authenticated-orcid":false,"given":"Md Amjad","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"},{"name":"Department of Physiology, Biochemistry and Pharmacology Chattogram Veterinary and Animal Sciences University  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shohel Al","family":"Faruk","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology Chattogram Veterinary and Animal Sciences University  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Ashfak Ahmed","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"},{"name":"Department of Pharmacy Jahangirnagar University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-106X","authenticated-orcid":false,"given":"Mohammad Nazmul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"},{"name":"Department of Pharmacy Jahangirnagar University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0658-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112215"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113650"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.111923"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00784"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"1","article-title":"Screening of Plant Macaranga peltata for In\u00a0Vitro Antioxidant Activity","volume":"3","author":"Dhanaraj S.","year":"2012","journal-title":"Int J Med Pharm Sci"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00177"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2047"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.02.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.56499\/jppres24.1997_13.2.662"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2362"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv462"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03665-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113565"},{"key":"e_1_2_11_16_1","unstructured":"Koster R.1959.\u201cAcetic Acid for Analgesics Screening \u201d."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.669638"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02201"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR2014.5396"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.71088"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70674"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2338-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1787\/9789264071001-en"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88599-5"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800050-2.00014-0"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00463-5"},{"key":"e_1_2_11_29_1","article-title":"Use of the Open Field Maze to Measure Locomotor and Anxiety\u2010Like Behavior in Mice","volume":"96","author":"Seibenhener M. 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