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This study further evaluated the effects of wild\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Prunus cerasifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    Ehrh. polyphenol extract (WPPE) on T2DM mice. WPPE treatment significantly lowered blood glucose, improved insulin resistance, and reduced hepatic oxidative stress and inflammation in T2DM mice. It could promote the production of short\u2010chain fatty acids and regulate the relative abundance of T2DM\u2010associated bacteria like\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    and\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    , and enhance hepatic glycogen synthesis through activation of the key gene involved in the PI3K\/AKT\/TBC1D4 pathway, resulting in hypoglycemic effect based on the gut\u2010liver axis. These findings support WPPE as a promising dietary candidate for T2DM management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71498","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:27:14Z","timestamp":1770611234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wild\n                    <scp>\n                      <i>Prunus cerasifera<\/i>\n                    <\/scp>\n                    Ehrh. Polyphenols Alleviate Hyperglycemia in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota\u2010\n                    <scp>SCFA<\/scp>\n                    s\u2010\n                    <scp>PI<\/scp>\n                    3\n                    <scp>K<\/scp>\n                    \/Akt\/\n                    <scp>TBC<\/scp>\n                    1\n                    <scp>D<\/scp>\n                    4 Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Xinpeng","family":"Cheng","sequence":"first","affiliation":[{"name":"National R&amp;D Center of Freshwater Fish Processing, College of Life Science Jiangxi Normal University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xie","sequence":"additional","affiliation":[{"name":"National R&amp;D Center of Freshwater Fish Processing, College of Life Science Jiangxi Normal University  Nanchang Jiangxi 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