{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:06:16Z","timestamp":1790690776440,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB25560"],"award-info":[{"award-number":["20242BAB25560"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plant\u2010derived exosome\u2010like nanovesicles (ELNs) have shown potential in the treatment of various diseases. This research sought to investigate the effects of\n                    <jats:italic>Pinellia pedatisecta<\/jats:italic>\n                    Schott\u2010derived ELNs (PPS\u2010ELNs) on colorectal cancer (CRC). PPS\u2010ELNs extracted from\n                    <jats:italic>Pinellia pedatisecta<\/jats:italic>\n                    Schott were characterized. CRC cell lines HCT116 and HT\u201029 were exposed to 10\u2009\u03bcg\/mL of PPS\u2010ELNs. Normal colon epithelial cells FHC were treated with different concentrations of PPS\u2010ELNs. CRC mice were treated with 12.5 or 25\u2009mg\/kg of PPS\u2010ELNs. Subsequent experiments, including cellular uptake assay, CCK\u20108 assay, colony formation assay, flow cytometry, Western blot, transmission electron microscopy, LysoTracker Red staining, immunofluorescence, ELISA, in\u00a0vivo imaging, TUNEL staining, immunohistochemistry, HE staining, and biochemical analysis, were conducted to explore the anti\u2010CRC effects and potential mechanisms of PPS\u2010ELNs. Lysosome inhibitor chloroquine was employed to elucidate the underlying mechanism in\u00a0vitro. The isolated PPS\u2010ELNs were successfully characterized. Cellular uptake of PPS\u2010ELNs was observed in CRC cell lines. Notably, PPS\u2010ELNs did not affect FHC cell viability, while significantly inhibiting proliferation and inducing apoptosis and mitophagy in CRC cell lines. Furthermore, PPS\u2010ELNs induced oxidative stress and reduced lysosomal damage in HCT116 cells. The effects of PPS\u2010ELNs on HCT116 cells were reversed by chloroquine. In CRC mice, PPS\u2010ELNs were primarily accumulated in tumors. PPS\u2010ELNs markedly reduced tumor growth, induced apoptosis, and decreased Ki67 expression. Additionally, PPS\u2010ELNs decreased Gal3 expression, increased autophagosomes, and altered mitophagy\u2010related protein levels in tumor tissues. Importantly, PPS\u2010ELNs displayed an excellent safety profile in\u00a0vivo. PPS\u2010ELNs inhibit CRC progression through the lysosome\u2010mediated mitophagy pathway.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71500","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:31:22Z","timestamp":1769599882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Pinellia pedatisecta<\/i>\n                    Schott\u2010Derived Exosome\u2010Like Nanovesicles Promote Apoptosis in Colorectal Cancer by Regulating the Lysosome\u2010Mediated Mitophagy Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Pingsheng","family":"Zhou","sequence":"first","affiliation":[{"name":"International Education College Jiangxi University of Chinese Medicine  Nanchang Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School Jiangxi University 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