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They have multifactorial modes of action such as antioxidant, anti\u2010inflammatory, and apoptotic, which render them useful in the prevention and treatment of prostate, breast, colon, bladder, and skin cancer. Phytosterol prevents cancer development by scavenging reactive oxidative species (ROS) and boosting antioxidant enzymes, thus inhibiting DNA damage and cell mutations that cause cancerous development. They also regulate important signal transduction processes such as NF\u2010kB, PI3K\/Akt, and MAPK\/ERK that drive cell growth, survival, and metastasis. Phytosterols induce apoptosis, block the cell cycle, and abrogate the invasion and metastasis of cancer cells, offering a multi\u2010manifestation treatment of cancer. Nevertheless, their clinical use is limited due to factors like low bioavailability, which can be overcome with research in nanotechnology and drug delivery schemes. 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