{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:06:21Z","timestamp":1790690781889,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010450","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endocrine disruptors such as bisphenol A (BPA) are increasingly associated with metabolic disorders, including metabolic dysfunction\u2010associated fatty liver disease (MASLD). This preclinical study investigates the effect of BPA on liver function and lipid metabolism in Wistar rats and evaluated the protective potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Myrtus communis<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil (EOMC) and vitamin E (Vit E). MASLD was induced in Wistar rats by oral administration of BPA (100\u2009mg\/kg\/day) for 30\u2009days. Rats were co\u2010treated with EOMC at doses of 50,100, or 200\u2009mg\/kg body weight, or Vit E at 100\u2009mg\/kg. Liver and kidney function markers, lipid profiles, oxidative stress parameters, and organ histology were assessed. BPA exposure significantly increased plasma liver enzymes (AST: 195,76\u2009\u00b1\u20094,47\u2009U\/L, ALT: 91,05\u2009\u00b1\u20090,58\u2009U\/L) and lipid levels (triglycerides: 1,30\u2009\u00b1\u20090,13\u2009g\/L) compared to controls, and elevated oxidative stress markers, including malondialdehyde (MDA). Co\u2010treatment with EOMC improved these parameters in a dose\u2010dependent manner. At 200\u2009mg\/kg, EOMC reduced plasma triglycerides 0,62\u2009\u00b1\u20090,09\u2009g\/L, corresponding to an approximate 52% decrease compared to the BPA\u2010only group, along with an approximately 84% reduction in hepatic MDA levels. Liver histology confirmed marked attenuation of steatosis and hepatocellular damage. Vitamin E showed similar protective effects, though slightly less pronounced. Both EOMC and Vit E demonstrated potential in mitigating against BPA\u2010induced MASLD. These findings indicate that EOMC may have a protective effect against fatty liver changes in this experimental model, but further studies are needed to confirm its relevance in humans.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71520","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:47:40Z","timestamp":1770616060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective Effects of\n                    <i>Myrtus communis<\/i>\n                    Essential Oil Against Bisphenol A\u2010Induced Metabolic Dysfunction\u2010Associated Fatty Liver Disease in Wistar Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8418-9427","authenticated-orcid":false,"given":"Mhimdi","family":"Mariem","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selmi","family":"Slimen","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Zammali","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Hraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8475-7854","authenticated-orcid":false,"given":"Soumaya","family":"Wahabi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallacqua","family":"Stefano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-1401","authenticated-orcid":false,"given":"Sebai","family":"Hichem","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources Higher Institute of Biotechnology of Beja, University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","article-title":"Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms","volume":"14","author":"AbdalHussin E. 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