{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:34:54Z","timestamp":1791491694307,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008036","name":"National Nutrition and Food Technology Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020481","name":"Shahid Beheshti University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hashimoto's thyroiditis (HT) is a chronic autoimmune condition characterized by persistent thyroid inflammation. Patients with HT may benefit from anti\u2010inflammatory strategies. This study was designed to examine the combined impact of an anti\u2010inflammatory diet and curcumin supplementation on inflammatory markers in individuals with HT. In this randomized controlled clinical trial, 57 individuals diagnosed with Hashimoto's thyroiditis (HT) in Tehran, Iran, were recruited and randomly allocated to two intervention arms. One group received an anti\u2010inflammatory diet in conjunction with 1500\u2009mg of curcumin daily, while the other group followed the same diet but was administered a placebo. Inflammatory biomarkers including high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), interleukin\u20106 (IL\u20106), and nuclear factor kappa B (NF\u2010\u03baB) were measured at the start of the study and again following a 12\u2010week supplementation period to assess the additive effect of curcumin. Curcumin supplementation resulted in a reduction in IL\u20106 (\u22125.28\u2009\u00b1\u20099.75,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). Additionally, it decreased hs\u2010CRP levels in patients with HT, with a mean reduction of \u22121.17\u2009\u00b1\u20095.70\u2009mg\/L, whereas the placebo group exhibited an increase of +1.53\u2009\u00b1\u20093.33\u2009mg\/L (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.305). Also, curcumin supplementation significantly reduced NF\u2010\u03baB levels in patients with HT (\u22120.09\u2009\u00b1\u20090.22 vs. 0.03\u2009\u00b1\u20090.15,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019), while the placebo group showed a slight increase (0.65\u2009\u00b1\u20090.16 to 0.68\u2009\u00b1\u20090.13). Curcumin, by reducing inflammation, can be effective as an adjunctive treatment alongside an anti\u2010inflammatory diet in individuals with HT. Additional studies are warranted.\n                  <\/jats:p>\n                  <jats:p>\n                    Name of the Registry: National Nutrition and Food Technology Research Institute. Trial Registration Number: NCT0597586. Date of Registration: 2023\u201008\u201004. URL of Trial Registry Record:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05975866?term\">https:\/\/www.clinicaltrials.gov\/study\/NCT05975866?term<\/jats:ext-link>\n                    = NCT05975866&amp;rank\u2009=\u20091.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71572","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:59:47Z","timestamp":1773291587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Additive Effects of Curcumin Supplementation in Addition to an Anti\u2010Inflammatory Diet on Inflammatory Indices in Patients With Hashimoto's Thyroiditis (\n                    <scp>HT<\/scp>\n                    ): A Double Blind Randomized Controlled Clinical Trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Fatemeh","family":"Bourbour","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Saeed Pathobiology and Genetics Lab  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niayesh","family":"Naghshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Yari","sequence":"additional","affiliation":[{"name":"Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedsina Moghimnejad","family":"hosseini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Kalbasi","sequence":"additional","affiliation":[{"name":"Internal Medicine Ward, Endocrinology and Metabolism Section Shahid Beheshti University of Medical Sciences, Iranian Diabetes Society President  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-2734","authenticated-orcid":false,"given":"Golbon","family":"Sohrab","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.11372"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2478\/enr-2018-0007"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6328"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1548832"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2018.09.002"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314710"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"26","article-title":"Aetiology of Thyroid Autoimmunity","volume":"30","author":"Attard C. 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