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To address this gap, a rapid and efficient method based on QuEChERS extraction and UPLC\u2013MS\/MS detection was developed for the simultaneous determination of two \u03b2\u2010carboline heterocyclic amines (harman and norharman) and seven mycotoxins (fumonisins B1, B2, B3 and aflatoxins B1, B2, G1, G2). The optimized extraction utilized a 30:20:50 (v\/v\/v) acetonitrile\/methanol\/water mixture. The method was rigorously validated, showing high sensitivity (LODs: 0.021\u20130.232\u2009ng\/g; LOQs: 0.100\u20130.587\u2009ng\/g), accuracy (recoveries: 80.4%\u2013109.3%), and reliability. When applied to real samples, the method not only confirmed its practicality across different matrices but also revealed a critical finding: the co\u2010occurrence of heterocyclic amines and mycotoxins, particularly in fried peanuts. This study provides an essential tool for integrated food safety surveillance and highlights the need for combined risk assessment of multiple contaminants.<\/jats:p>","DOI":"10.1002\/fsn3.71593","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:40:45Z","timestamp":1775191245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a Novel, Simultaneous Determination Method for Heterocyclic Amines and Mycotoxins in Fried Food by\n                    <scp>UPLC<\/scp>\n                    \u2013\n                    <scp>MS<\/scp>\n                    \/\n                    <scp>MS<\/scp>\n                    Combined With\n                    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Shangqiu Normal University  Shangqiu Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-1992","authenticated-orcid":false,"given":"Maomao","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University  Wuxi Jiangsu 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