{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:36:18Z","timestamp":1790217378295,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Exercise\u2010induced fatigue (EIF) is closely associated with impaired glycometabolism in skeletal muscle. This study investigated the protective effects of Ganoderic acid A (GAA) on glycometabolism in EIF mice and explored its underlying mechanisms. 60 KM mice were divided into five groups: a blank control (BC), a model control (MC), and three GAA\u2010treated groups (20, 40, and 60\u2009mg\/kg\/d). After a 7\u2010week intervention, exhaustive treadmill tests and biochemical analyses were conducted to assess fatigue resistance, metabolic parameters, and molecular pathways. GAA administration significantly prolonged the exhaustive running time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), reduced serum levels of blood urea nitrogen (BUN), creatine kinase (CK), lactate dehydrogenase (LDH), and lactate (LD) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and increased glycogen content in the liver and gastrocnemius muscle. Mechanistically, GAA increased AMPK phosphorylation, suggesting activation of the AMPK pathway, upregulated PGC\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and GLUT4 expression, and enhanced succinate dehydrogenase (SDH) and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010ATPase activities. The results demonstrate that GAA alleviates EIF by enhancing energy metabolism through the AMPK\/PGC\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/GLUT4 pathway. These findings highlight GAA as a promising natural supplement for combating exercise\u2010induced fatigue by improving glycometabolism.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71596","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:36:12Z","timestamp":1772966172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise\u2010Induced Fatigue via\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>PGC<\/scp>\n                    \u20101\u03b1 Pathway Activation"],"prefix":"10.1002","volume":"14","author":[{"given":"Jialin","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Sports and Health Guangxi College of Sports Education  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanju","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-5013","authenticated-orcid":false,"given":"Jingrong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Sports and Health Guangxi College of Sports Education  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuju","family":"Shang","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-5364","authenticated-orcid":false,"given":"Taotao","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Physical Education and Health Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00669-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114561"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.10.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2016.1249524"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.07.023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"Chen H. 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