{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:09:56Z","timestamp":1789168196348,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aimed to systematically assess the effects of Chamomile consumption on some biochemical parameters and clinical symptoms in patients with polycystic ovary syndrome (PCOS). The search was performed across the databases PubMed, Web of Science, Scopus, and Google Scholar using relevant keywords, with no language or date restrictions, up to the 4th of December 2024. Given the limited number of studies, results from both human and animal research were considered. The risk of bias for included studies was evaluated. For clinical studies, meta\u2010analyses were conducted using Stata, and a random\u2010effects model was used to estimate effect sizes. Four animal and four human studies were qualified for this review. Almost all animal studies indicated that Chamomile improved clinical, hormonal, and oxidative stress parameters in PCOS. Furthermore, almost all human studies have shown that Chamomile supplementation improves the clinical features of PCOS. However, the pooled analysis of two eligible human studies showed that there was no statistically significant effect of Chamomile supplementation on serum lipid profile including LDL\u2010C (ES\u2009=\u20091.73, 95% CI (\u22126.49, 9.94),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.680), TG (ES\u2009=\u2009\u22127.23, 95% CI (\u221229.34, 14.89),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.522), and HDL\u2010C (ES\u2009=\u2009\u22120.07, 95% CI (\u22125.85, 5.70),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.980). Moreover, the pooled analysis of three eligible human studies demonstrated no statistically significant effect of Chamomile on serum testosterone levels (ES\u2009=\u20095.05, 95% CI\u2009=\u2009(\u22121.38, 11.49),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.124). Overall, animal studies have demonstrated the potential benefits of Chamomile consumption in the treatment of PCOS, possibly through anti\u2010androgenic, anti\u2010inflammatory, analgesic, and antioxidant effects. In contrast, human studies yielded heterogeneous findings, with improvements in clinical features but no significant impact on serum testosterone or lipid profile parameters. Therefore, further well\u2010designed clinical trials are needed to make more definitive decisions.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71600","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:00:56Z","timestamp":1772964056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Potential Effects of Chamomile (\n                    <scp>\n                      <i>Matricaria chamomilla<\/i>\n                      L\n                    <\/scp>\n                    .) in Polycystic Ovary Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Zahra","family":"Firoozi","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roghayeh","family":"Molani\u2010Gol","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-2129","authenticated-orcid":false,"given":"Vahideh","family":"Ebrahimzadeh\u2010Attari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Nutrition, Faculty of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-5438","authenticated-orcid":false,"given":"Aida","family":"Malek\u2010Mahdavi","sequence":"additional","affiliation":[{"name":"Tuberculosis and Lung Disease Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052734"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18502\/jfrh.v16i4.11355"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.15296\/ijwhr.2023.31"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.06.066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010088"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119558378"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2001.tb03986.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100085"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5138\/09750185.2249"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18502\/tim.v8i4.14480"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12040479"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.81958"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20101696"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2016.11.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_90_17"},{"issue":"5","key":"e_1_2_9_17_1","first-page":"70","article-title":"The Effect of Hydroalcoholic Extract of Fennel (Foeniculum vulgare) Seed on Serum Levels of Sexual Hormones in Female Wistar Rats With Polycystic Ovarian Syndrome (PCOS)","volume":"17","author":"Karampoor P.","year":"2014","journal-title":"HBI Journals"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biotech12010004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18050680"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"22","article-title":"Effects of Chamomile Hydro\u2010Alcoholic Extract (Matricaria chamomilla) on the Aborted Fetuses, Serum Sex Hormones and Ovarian Follicles in Adult Female Rats","volume":"17","author":"Mirzakhani Z.","year":"2017","journal-title":"ARUMSJ"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms059"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.30476\/ijcbnm.2021.87219.1417"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2025.103192"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010014\u20100170\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.08.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2016.1206562"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101284"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010023\u201003936\u20107"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041454"},{"issue":"3","key":"e_1_2_9_30_1","first-page":"169","article-title":"Effects of Chamomile Extract on Biochemical and Clinical Parameters in a Rat Model of Polycystic Ovary Syndrome","volume":"11","author":"Zafari Zangeneh F.","year":"2010","journal-title":"Journal of Reproduction & Infertility"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010023\u201001286\u20106"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20102419"}],"container-title":["Food Science &amp; 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