{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:10:31Z","timestamp":1789168231672,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Several studies have confirmed that chlorogenic acid (CGA) has beneficial effects on intestinal health. This study aimed to investigate the protective effect and underlying mechanism of CGA in lipopolysaccharide (LPS)\u2010induced intestinal injured mice. Histological analysis of duodenal epithelial morphology and tight junction\u2010related gene expression indicated that CGA helps preserve intestinal barrier integrity. Quantitative PCR analysis showed that CGA suppressed the expression of pro\u2010inflammatory factors including interferon\u2010\u03b3 (Ifn\u2010\u03b3), interleukin\u20107 (Il\u20107),\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.biomart.cn\/news\/16\/129807.htm\">tumor necrosis factor\u2010\u03b1<\/jats:ext-link>\n                    (Tnf\u2010\u03b1), and upregulated the anti\u2010inflammatory cytokines interleukin\u201010 (Il\u201010) in LPS\u2010induced enteritis mice. Furthermore, compared to LPS\u2010treatment mice, CGA supplementation sustained intestinal stem cell (ISCs) activity, including proliferation and differentiation. Additionally, CGA inhibited LPS\u2010induced activation of the Janus kinase\/signal transducers and activators of transcription (JAK\/STAT) pathway, as evidenced by a reduction in the expression of Jak2, Jak3, and Stat1. This effect was comparable to that of Tofacitinib, a known JAK\/STAT pathway inhibitor. Collectively, these findings suggest that CGA protects intestinal epithelial integrity and alleviates intestinal injury by suppressing inflammatory responses and preserving ISC activity via inhibition of the JAK\/STAT signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71602","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:45:36Z","timestamp":1772988336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chlorogenic Acid Ameliorate Lipopolysaccharide Induced Intestinal Acute Inflammatory Injury via Inhibiting Cytokines Production and Activating Intestinal Stem Cells"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7278-9883","authenticated-orcid":false,"given":"Kejin","family":"Li","sequence":"first","affiliation":[{"name":"School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou 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