{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:06:54Z","timestamp":1790172414812,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006402","name":"Fasa University of Medical Sciences","doi-asserted-by":"publisher","award":["400286"],"award-info":[{"award-number":["400286"]}],"id":[{"id":"10.13039\/501100006402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Metabolic dysfunction associated steatotic liver disease (MASLD) is a common chronic liver disorder characterized by hepatic steatosis, inflammation, and progression to fibrosis and cirrhosis. Despite advances in pharmacotherapy, including thyroid hormone receptor \u03b2 agonists (resmetirom) and GLP 1 receptor agonists, no universally accepted curative treatment exists. Nutraceuticals such as quercetin offer promising hepatoprotective effects, yet their clinical translation is limited by low bioavailability and stability. In this study, we evaluated the therapeutic potential of chitosan\u2010encapsulated quercetin (Que\u2010CH) nanoparticles in a high\u2010fat diet rat model of MASLD. Que\u2010CH nanoparticles were characterized by particle size (~190\u2009nm), positive zeta potential (+56.5\u2009mV), and 65% encapsulation efficiency. Treatment with Que\u2010CH significantly reduced serum IL\u20101\u03b2, improved liver histology by decreasing macro\u2010 and microvesicular steatosis, and lowered the Bax\/Bcl\u20102 ratio, indicating reduced hepatocyte apoptosis. These results suggest that Que\u2010CH nanoparticles enhance the bioactivity of quercetin, exerting anti\u2010inflammatory, anti\u2010apoptotic, and lipid\u2010lowering effects in MASLD. This study highlights the potential of nanocarrier\u2010based nutraceutical interventions as complementary strategies for liver steatosis management, while further mechanistic studies and pharmacokinetic evaluations are warranted to support clinical translation.<\/jats:p>","DOI":"10.1002\/fsn3.71617","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:00:41Z","timestamp":1775710841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatoprotective Effects of Quercetin\u2010Chitosan Nanoparticles on Nonalcoholic Fatty Liver Disease: In\u00a0Vivo Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5054-6990","authenticated-orcid":false,"given":"Behina","family":"Babaalizadeh","sequence":"first","affiliation":[{"name":"Student Research Committee Fasa University of Medical Sciences  Fasa 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