{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:10:15Z","timestamp":1789168215846,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TDK\u2010 2023\u201013279"],"award-info":[{"award-number":["TDK\u2010 2023\u201013279"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the individual and combined effects of the multi\u2010strain probiotic VSL#3 and curcumin on glycemic control, insulin resistance, and oxidative stress (OS) in a rat model of T2DM induced by a high\u2010fat diet (HFD) and streptozotocin (STZ). Forty male Sprague\u2013Dawley rats were divided into five groups: negative control, positive control (PC) induced with HFD and STZ, VSL#3 probiotic (PRO) (2.5\u2009\u00d7\u200910\n                    <jats:sup>10<\/jats:sup>\n                    \u2009CFU\/day VSL#3), curcumin (CUR) (200\u2009mg\/kg\/day curcumin), and combination of VSL#3 and curcumin (PRO+CUR) (2.5\u2009\u00d7\u200910\n                    <jats:sup>10<\/jats:sup>\n                    \u2009CFU\/day VSL#3\u2009+\u2009200\u2009mg\/kg\/day curcumin). At the end of 8\u2009weeks, the study assessed the effects of these interventions on body weight, food intake, fasting blood glucose, and insulin resistance (HOMA\u2010IR). Additionally, serum and pancreatic tissue antioxidant parameters, were measured, including TAC, SOD, CAT, GP\n                    <jats:italic>x<\/jats:italic>\n                    , and MDA. VSL#3 and curcumin individually improved body weight, fasting blood glucose, and antioxidant enzyme activities. The PRO+CUR group showed the highest body weight gain and lower fasting blood glucose (353.83\u2009\u00b1\u200939.48\u2009mg\/dL) compared to the PC group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). However, the PRO+CUR combination did not yield the expected synergistic effects, likely due to curcumin's low bioavailability and prooxidant effects. Serum TAC was highest in the CUR group (0.78\u2009\u00b1\u20090.05\u2009U\/ng), whereas the PRO+CUR group showed reduced TAC (0.16\u2009\u00b1\u20090.02\u2009U\/ng). HOMA\u2010IR values increased in the PRO and CUR groups, but no significant change was observed in the PRO+CUR group. This study demonstrates the therapeutic potential of probiotics and curcumin in T2DM. Probiotics enhanced antioxidant defenses and reduced OS, but the combination with curcumin showed no synergistic effects, likely due to curcumin's bioavailability.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71624","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:42:25Z","timestamp":1773117745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Probiotics and Curcumin Did Not Alter Low\u2010Dose Streptozotocin\u2010Induced Hyperglycemia and Oxidative Stress in a Rat Model"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-7860","authenticated-orcid":false,"given":"Meliha","family":"Cavdar","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Institute of Health Sciences Erciyes University  Kayseri 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