{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:01:13Z","timestamp":1790172073501,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Asthma\u2010COPD overlap (ACO) is associated with increased mortality and disease burden compared to asthma or COPD alone. Diet, a modifiable risk factor, influences inflammation and lung health, yet its impact on ACO mortality remains understudied. This study investigates the synergistic effects of the Healthy Eating Index (HEI\u20102015) and Dietary Inflammatory Index (DII) on all\u2010cause mortality in ACO patients. Using data from the National Health and Nutrition Examination Survey (NHANES) 2007\u20132018, we analyzed 609\u2009U.S. adults with ACO, defined by clinical and spirometric criteria. Dietary patterns were assessed via HEI\u20102015 (diet quality) and DII (inflammatory potential). Cox proportional hazards models evaluated associations with mortality, adjusting for sociodemographic, lifestyle, and clinical confounders. Restricted cubic spline analyses explored non\u2010linear relationships, and Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key dietary components for a prognostic nomogram. Healthier diets (higher HEI\u20102015) were associated with lower mortality risk (HR\u2009=\u20090.98, 95% CI: 0.97\u20130.99, highest quartile), while pro\u2010inflammatory diets (higher DII) increased risk (HR\u2009=\u20091.13, 95% CI: 1.04\u20131.22). The combination of healthy and anti\u2010inflammatory diets showed the strongest protective effect (HR\u2009=\u20090.68, 95% CI: 0.47\u20130.98). LASSO regression identified PUFA, total dairy, whole fruit, and n\u20106 fatty acids as key predictors, incorporated into a nomogram with moderate predictive accuracy (AUC: 0.64\u20130.67). Kaplan\u2013Meier curves confirmed better survival in low\u2010risk dietary groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Subgroup analyses showed stronger effects in mild drinkers and non\u2010hypertensive patients. High\u2010quality, anti\u2010inflammatory diets synergistically reduce mortality in ACO patients. Targeted nutritional interventions emphasizing whole fruits, dairy, and healthy fats may improve outcomes. Future research should validate these findings through interventional trials.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71657","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:06:47Z","timestamp":1783494407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diet Quality, Dietary Inflammatory Potential, and All\u2010Cause Mortality in U.S. Adults With Asthma\u2010\n                    <scp>COPD<\/scp>\n                    Overlap"],"prefix":"10.1002","volume":"14","author":[{"given":"Jixiang","family":"Li","sequence":"first","affiliation":[{"name":"Geriatrics Department The Second People's Hospital of Meishan City, Renshou County People's Hospital  Meishan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Second People's Hospital of Meishan City  Meishan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Second People's Hospital of Meishan City  Meishan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Deyang People's Hospital  Deyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4725-3935","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Second People's Hospital of Meishan City  Meishan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4368-8340","authenticated-orcid":false,"given":"Rongrong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2017.1326858"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-022-00732-z"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201707-571OC"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062985"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2011.611200"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2019.1634039"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050708"},{"issue":"10","key":"e_1_2_14_9_1","first-page":"19s","article-title":"The Asthma\u2010COPD Overlap Syndrome","volume":"32","author":"Freiler J. 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