{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:50:39Z","timestamp":1792525839756,"version":"4.5.0"},"reference-count":95,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Periodontitis is increasingly recognized as a non\u2010communicable chronic oral disease in which sustained oxidative stress and cellular senescence drive low\u2010grade inflammation and tissue destruction.\n                    <jats:italic>Polygonati Rhizoma (PR)<\/jats:italic>\n                    , a traditional Chinese herb widely consumed as a functional food ingredient, is rich in antioxidant polyphenols and polysaccharides, yet its role in modulating senescence of periodontal ligament stem cells (PDLSCs) remains unclear. This study integrated network pharmacology and experimental validation to elucidate the protective effects and mechanisms of\n                    <jats:italic>PR<\/jats:italic>\n                    against oxidative stress\u2010induced PDLSC senescence. Putative\n                    <jats:italic>PR<\/jats:italic>\n                    components and targets related to periodontitis and aging were collected to construct a protein\u2013protein interaction (PPI) network, from which 21 core targets were predicted. These included key inflammation\u2010 and senescence\u2010related proteins such as TP53, RELA (p65), TNF\u2010\u03b1, TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, IL\u20106, IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , CXCL8, and MMP\u20109. Gene Ontology and KEGG enrichment analyses highlighted pathways involved in cellular senescence, NF\u2010\u03baB signaling, and oxidative stress responses. Molecular docking suggested strong binding affinities between major\n                    <jats:italic>PR<\/jats:italic>\n                    constituents and putative core protein targets. In an in\u00a0vitro oxidative stress\u2010induced PDLSC senescence model,\n                    <jats:italic>PR<\/jats:italic>\n                    \u2010medicated serum, with Metformin as a positive control, significantly reduced intracellular oxidative stress markers, alleviated cell\u2010cycle arrest, and downregulated senescence\u2010associated secretory phenotype (SASP) cytokines.\n                    <jats:italic>PR<\/jats:italic>\n                    showed anti\u2010senescent efficacy comparable to Metformin while exhibiting distinct molecular signatures. These findings indicate that\n                    <jats:italic>PR<\/jats:italic>\n                    exerts multi\u2010component, multi\u2010target modulation of NF\u2010\u03baB\u2010centered inflammatory and senescence pathways in PDLSCs, thereby mitigating oxidative stress\u2010induced cellular aging. As an edible, functional herb,\n                    <jats:italic>PR<\/jats:italic>\n                    may represent a promising dietary adjunct for the prevention and management of periodontitis linked to cellular senescence.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71672","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:09:05Z","timestamp":1781082545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Polygonati Rhizoma<\/i>\n                    Attenuates Oxidative Stress\u2010Induced Senescence in Periodontal Ligament Stem Cells"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8231-3872","authenticated-orcid":false,"given":"Xinran","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, The Second Medical Center, School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, The Second Medical Center, School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, The Second Medical Center, School of Stomatology The Fourth 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