{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:09:30Z","timestamp":1789168170957,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In traditional Chinese medicine,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Arachis hypogaea<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. root extract (AHRE), and other parts of the plant historically have been used to manage benign prostatic hyperplasia (BPH). Hence, to evaluate the therapeutic effect of AHRE on testosterone\u2010induced BPH in ICR mice, BPH was induced by daily subcutaneous testosterone propionate injections (6\u2009mg\/kg BW) in olive oil for 30\u2009days. AHRE was orally administered at 100, 200, and 300\u2009mg\/kg BW daily, with finasteride (1\u2009mg\/kg BW) used as the positive control. HPLC\u2010qTOF\u2010MS\/MS identified 19 compounds in 70% ethanolic AHRE, with resveratrol quantified at 1.12\u2009mg\/g dry weight. Prostate weight (PW), prostatic index (PI), histopathological changes, serum concentrations of prostatic acid phosphatase (PAP), dihydrotestosterone (DHT), testosterone (T), estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ), and T\/E\u2082 ratio, along with androgen receptor (AR) levels and the relative mRNA expression of\n                    <jats:italic>hypoxia\u2010inducible factor\u20101\u03b1<\/jats:italic>\n                    (\n                    <jats:italic>HIF\u20101\u03b1<\/jats:italic>\n                    ),\n                    <jats:italic>estrogen receptors<\/jats:italic>\n                    (\n                    <jats:italic>ER\u2010\u03b1 and ER\u2010\u03b2<\/jats:italic>\n                    ),\n                    <jats:italic>lipoxygenase\u20105<\/jats:italic>\n                    (\n                    <jats:italic>LOX\u20105<\/jats:italic>\n                    ), and\n                    <jats:italic>cyclooxygenase\u20102<\/jats:italic>\n                    (\n                    <jats:italic>COX\u20102<\/jats:italic>\n                    ) were measured. High\u2010dose AHRE (300\u2009mg\/kg) reduced PW by 84.07%, significantly reduced glandular hyperplasia, prostatic cell counts, PAP, DHT, and AR levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). It also downregulated relative mRNA expression of inflammation\u2010related genes, including\n                    <jats:italic>ER\u2010\u03b1<\/jats:italic>\n                    (1.6\u2010fold),\n                    <jats:italic>5\u2010LOX<\/jats:italic>\n                    (1.65\u2010fold), and\n                    <jats:italic>COX\u20102<\/jats:italic>\n                    (1.36\u2010fold). Preliminary gut microbiota analysis revealed treatment\u2010associated increases in the relative abundance of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , which showed robust negative correlations with PW (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u2009\u22120.95,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.001), PI (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u2009\u22120.96,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.001), and inflammatory markers, a genus linked to enhanced gut barrier function and control of systemic inflammation, potentially contributing to the observed improvements in BPH phenotypes.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71682","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:15:55Z","timestamp":1774329355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>Arachis hypogaea<\/i>\n                    <\/scp>\n                    L. Root Extract Mitigates Testosterone Propionate\u2010Induced Benign Prostatic Hyperplasia in\n                    <scp>ICR<\/scp>\n                    Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-9479","authenticated-orcid":false,"family":"Samee\u2010Ullah","sequence":"first","affiliation":[{"name":"School of Agricultural Engineering and Food Science Shandong University of Technology  Zibo P.R. China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability  Zibo Shandong P.R. China"},{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-8029","authenticated-orcid":false,"given":"Faryal","family":"Shaukat","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering and Food Science Shandong University of Technology  Zibo P.R. China"},{"name":"Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability  Zibo Shandong P.R. 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