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This study explored its therapeutic effects and mechanisms using a dehydroepiandrosterone (DHEA)\u2010induced PCOS mouse model and granulosa cells (GCs). Salidroside was found to restore estrous cyclicity, improve ovarian morphology, and rebalance serum hormone levels. Mechanistically, it suppressed ROS\u2010mediated AKT\/NF\u2010\u03baB signaling, inhibited NLRP3 inflammasome activation, and reduced proinflammatory cytokines. Network pharmacology and molecular docking identified AKT as a core target, validated by CETSA and DARTS assays. Furthermore, salidroside disrupted NLRP3\u2010driven latent TGF\u2010\u03b21 (LAP\u2010TGF\u03b21) activation, downregulated TGF\u2010\u03b2\u2010SMAD2\/3 signaling, and attenuated ovarian fibrosis along with abnormal hyaluronan synthase 2 (HAS2) expression. These results highlight salidroside as a promising natural candidate for alleviating PCOS through coordinated anti\u2010inflammatory and antifibrotic mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71692","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:50:11Z","timestamp":1775289011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salidroside Ameliorates Polycystic Ovary Syndrome in Mice by Regulating the\n                    <scp>AKT<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    \u2010\n                    <scp>HAS2<\/scp>\n                    Axis"],"prefix":"10.1002","volume":"14","author":[{"given":"Jing\u2010hang","family":"Li","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Model, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Model, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Model, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Yan","family":"He","sequence":"additional","affiliation":[{"name":"Animal Genome Editing Technology Innovation Center, Jilin Province, College of Animal Science Jilin University  Changchun 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Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Animal Genome Editing Technology Innovation Center, Jilin Province, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Model, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010lei","family":"Yan","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Model, College of Animal Science Jilin University  Changchun 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