{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:06:39Z","timestamp":1790172399253,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      To evaluate the effects of a multi\u2010strain probiotic formula,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      subsp.\n                      <jats:italic>lactis<\/jats:italic>\n                      BLa80,\n                      <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                      LRa05, and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Bifidobacterium breve<\/jats:italic>\n                      <\/jats:styled-content>\n                      BBr60, on inflammation, metabolism, and the gut microbiota in patients with type 2 diabetes mellitus (T2DM). In a randomized, double\u2010blind, placebo\u2010controlled trial, 80 adults with T2DM received either the probiotic or a placebo in addition to standard hypoglycemic therapy for 12\u2009weeks. We assessed inflammatory cytokines, glycemic indices, serum amino acids, bile acids (BAs), short\u2010chain fatty acids (SCFAs), and gut microbiota composition. Compared with the placebo group, the probiotic intervention led to a significant reduction in the levels of IL\u201017 and TNF\u2010\u03b1 (\n                      <jats:italic>p\u2009&lt;\u20090.05<\/jats:italic>\n                      ), reduced serum concentrations of threonine, isoleucine, and arginine. Additionally, the BA profile was markedly altered, revealing 16 differential metabolites that were associated with pivotal metabolic pathways. SCFA analysis showed higher isobutyric and isovaleric acid after supplementation. The probiotic group also exhibited significant reductions in total glycated hemoglobin (GHb) and fasting plasma glucose (FPG,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Microbiome analyses indicated decreased alpha\u2010diversity and distinct beta\u2010diversity shifts, including increased Gemmatimonadota and reduced\n                      <jats:italic>Clostridium<\/jats:italic>\n                      abundance in the probiotic group. This multi\u2010strain probiotic modulated inflammatory responses, metabolic profiles, including BA metabolism and SCFAs, and gut microbiota composition in T2DM, supporting its potential as an adjunct to metabolic management.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT06440486\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/fsn3.71735","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:07:25Z","timestamp":1775804845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi\u2010Strain Probiotics\n                    <scp>BLa80<\/scp>\n                    ,\n                    <scp>LRa05<\/scp>\n                    , and\n                    <scp>BBr60<\/scp>\n                    Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Sijia","family":"Zhu","sequence":"first","affiliation":[{"name":"Cancer Biotherapy Key Laboratory of Nanchong Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"He","sequence":"additional","affiliation":[{"name":"Cancer Biotherapy Key Laboratory of Nanchong Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Cancer Biotherapy Key Laboratory of Nanchong Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Song","sequence":"additional","affiliation":[{"name":"Cancer Biotherapy Key Laboratory of Nanchong Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-0849","authenticated-orcid":false,"given":"Kang","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Biotherapy Key Laboratory of Nanchong Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Fang","sequence":"additional","affiliation":[{"name":"Wecare Probiotics R&amp;D Centers (WPC) Wecare Probiotics Co., Ltd  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169059"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252010871"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12645"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA119000311"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-021-00446-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121414"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.770861"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13091017"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01308-5"},{"issue":"12","key":"e_1_2_12_11_1","article-title":"The Gut Microbiome's Influence on Incretins and Impact on Blood Glucose Control","volume":"12","author":"Dulai A. 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