{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:38:03Z","timestamp":1793806683591,"version":"4.6.1"},"reference-count":83,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the anti\u2010aging properties of\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    \u2010derived Parishin extracts (GEPE) by exploring its regulatory effects on oxidative stress, inflammatory responses, apoptosis, and metabolism. Network pharmacology identified 27 active components with parishins as core and 250 anti\u2010aging intersection targets of\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    . Molecular docking confirmed strong binding activity of parishins to key targets such as EGFR, AKT1, and ALB. In\u00a0vitro experiments showed that the GEPE concentration dependently reduced the activity of senescence marker SA\u2010\u03b2\u2010gal in D\u2010galactose\u2010induced senescent mouse microglial cell (BV2). In\u00a0vivo experiments showed that GEPE improved cognitive and muscle functions, elevated organ indices of liver, thymus, and spleen, alleviated hepatic lipid accumulation and neuronal damage, reduced oxidative stress, inhibited inflammatory responses and cell apoptosis, and corrected metabolic disorders in D\u2010galactose\u2010induced aging mice. These findings demonstrate that GEPE is associated with attenuated aging, potentially through coordinated modulation of oxidative stress, inflammation, apoptosis, and metabolic homeostasis, highlighting its potential as a candidate for anti\u2010aging interventions.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71737","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:51:45Z","timestamp":1775285505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Gastrodia elata<\/i>\n                    \u2013Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2779-5343","authenticated-orcid":false,"given":"Zhu","family":"Li","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihuang","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-1995","authenticated-orcid":false,"given":"Peng","family":"Tang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"},{"name":"Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia, College of Agronomy and Life Sciences Zhaotong University  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01143-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03483-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-019-09837-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976550"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16932"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-023-10684-w"},{"issue":"8","key":"e_1_2_11_8_1","article-title":"Inflammaging: The Next Challenge\u2010Exploring the Role of Gut Microbiota, Environmental Factors, and Sex Differences","volume":"12","author":"Caldarelli M.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0320572"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123119"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2225-4110(16)30054-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70408"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61460-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00957-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.170"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00238A"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.09.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9813-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00976-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422421000202"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00169-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7105"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117128"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114646"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.07802"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2268"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153576"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103279"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2021.07.004"},{"issue":"4","key":"e_1_2_11_32_1","first-page":"1374","article-title":"Longevity\u2010Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation","volume":"14","author":"Huang Y.","year":"2023","journal-title":"Aging and Disease"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.10.009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.06.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117891"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mocell.2024.100102"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12041-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac135"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00802-0"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139468"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119583"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113964"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03698-7"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-021-09910-5"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14081008"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1450337"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22-1033"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100875"},{"issue":"1","key":"e_1_2_11_51_1","article-title":"NF\u2010\u03baB\u2010Specific Suppression in Cardiomyocytes Unveils Aging\u2010Associated Responses in Cardiac Tissue","volume":"13","author":"Morgado L. A. L.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184331"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.103225"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9604-5"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00455-5"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13631"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41067"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf3208"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-118"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05215-7"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14122008"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03975-y"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2025.105000"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43292-1"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214571"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155518"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx374"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121173"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57992-3"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07701-9"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads4957"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00491-8"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.04042"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072036"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad518"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14456"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.09.050"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.877099"},{"issue":"1","key":"e_1_2_11_79_1","first-page":"1182","article-title":"Neuroprotective Effect of Polysaccharides From Gastrodia elata Blume Against Corticosterone\u2010Induced Apoptosis in PC12 Cells via Inhibition of the Endoplasmic Reticulum Stress\u2010Mediated Pathway","volume":"17","author":"Zhou B.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112940"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155251"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189097"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1641443"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00663-7"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:38:59Z","timestamp":1790170739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/fsn3.71737"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71737","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71737"}}