{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:06:54Z","timestamp":1791022014976,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016208","name":"University of Chittagong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016208","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Baccaurea motleyana<\/jats:italic>\n                    <\/jats:styled-content>\n                    (Rambai) is traditionally consumed in Southeast Asia and used ethnomedicinally, yet its toxicological profile remains unclear. This study evaluated the acute and subacute oral toxicity of its aqueous fruit extract (AE\u2010BMF) in Wistar rats. AE\u2010BMF was prepared from fresh pulp. Acute toxicity was assessed at 2000 mg\/kg, while subacute toxicity was tested for 28\u2009days at 400 mg\/kg\/day and 800 mg\/kg\/day. Physiological, hematological, biochemical, and histopathological parameters were evaluated. No mortality or overt toxicity was observed in the acute study (LD\n                    <jats:sub>50<\/jats:sub>\n                    &gt;\u20092000 mg\/kg). In the subacute study, AE\u2010BMF at 800 mg\/kg reduced body weight gain, water intake, and food intake, and increased relative liver weight by 15.8% (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.05). Biochemical analysis showed reductions in creatinine (0.50\u2009\u00b1\u20090.03\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01), uric acid (9.1\u2009\u00b1\u20090.6\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01), total cholesterol (73.5\u2009\u00b1\u20093.1\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01), and triglycerides (39.8\u2009\u00b1\u20093.3\u2009mg\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001) at 800\u2009mg\/kg dose. ALT rose moderately at 800\u2009mg\/kg (108.4\u2009\u00b1\u20096.0\u2009U\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Hematological changes included increased RBC (7.70\u2009\u00b1\u20090.28\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \/mm\n                    <jats:sup>3<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), hemoglobin (14.4\u2009\u00b1\u20090.3\u2009g\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001), platelets (585\u2009\u00b1\u200918\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/mm\n                    <jats:sup>3<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001), and lymphocytes (57.3%\u2009\u00b1\u20091.9%,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01). Histology confirmed normal kidneys with only mild hepatic alterations at a dose of 800 mg\/kg. AE\u2010BMF is safe at doses up to 800 mg\/kg, demonstrating hypolipidemic, hematopoietic, and immunostimulatory effects. Mild hepatic changes at higher doses suggest the need for cautious use and longer\u2010term studies.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71744","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:39:29Z","timestamp":1775803169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute and Subacute Oral Toxicity Evaluation of\n                    <scp>\n                      <i>Baccaurea motleyana<\/i>\n                    <\/scp>\n                    Fruit Extract in Wistar Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9400-8733","authenticated-orcid":false,"given":"Md. Mahmudul","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftekhar Alam","family":"Bhuyan","sequence":"additional","affiliation":[{"name":"Department of Dentistry Chittagong Medical University  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ekramul Haque","family":"Ekram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-8638","authenticated-orcid":false,"given":"Nawreen Monir","family":"Proma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-1086","authenticated-orcid":false,"given":"Mohammed Kamrul","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chittagong 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