{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:25Z","timestamp":1790172445771,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40468"],"award-info":[{"award-number":["2023JJ40468"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To investigate the antioxidant effects and underlying mechanisms of\n                    <jats:italic>Ampelopsis grossedentata<\/jats:italic>\n                    flavonoids (AGF) in rats fed a high\u2010fat diet. In this study, we established a basal diet group, a high\u2010fat diet group, a high\u2010fat diet combined with Xuezhikang group, and high\u2010fat diet groups supplemented with low, medium, and high doses of AGF. After 7\u2009weeks of feeding, relevant physiological antioxidant indicators and the antioxidant effects mediated by gut microbiota were measured. The results demonstrated that: (1) AGF significantly increased the gene expression, protein levels, and enzymatic activity of CAT and SOD in the livers of rats fed a high\u2010fat diet, thereby increasing the total antioxidant capacity and reducing power in serum. (2) Simultaneously, AGF demonstrated strong free radical (DPPH, hydroxyl, superoxide anion, and ABTS) scavenging capacity, accompanied by a reduction in hydrogen peroxide content and anti\u2010lipid peroxidation activity. (3) Furthermore, AGF significantly decreased the levels of pro\u2010inflammatory cytokines (IL\u20106, IL\u20101\u03b2, TNF\u2010\u03b1) in the livers of high\u2010fat diet\u2010fed rats. (4) Additionally, flavonoids enriched the diversity of gut microbiota, optimized microbial structure, and increased the abundance of beneficial microbes (such as\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>norank_f__Eubacterium_coprostanoligenes_group<\/jats:italic>\n                    ,\n                    <jats:italic>Enterorhabdus<\/jats:italic>\n                    ,\n                    <jats:italic>Butyricicoccus<\/jats:italic>\n                    , and\n                    <jats:italic>Clostridium_innocuum_group<\/jats:italic>\n                    ), which showed positive correlations with antioxidant\u2010related physiological parameters. In conclusion, AGF significantly alleviated high\u2010fat diet\u2010induced oxidative stress and liver injury in rats, providing a theoretical foundation for developing H\u2010AGF as a functional ingredient for use in functional foods, pharmaceuticals, and skincare products.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71746","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:29:48Z","timestamp":1776684588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ampelopsis Grossedentata Flavonoids Alleviate Hepatic Damage Through Remodeling Intestinal Microflora and Reducing Oxidative Stress in Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-6058","authenticated-orcid":false,"given":"Hao","family":"Shi","sequence":"first","affiliation":[{"name":"College of Life and Environmental Sciences Hunan University of Arts and Science  Changde Hunan China"},{"name":"College of Agriculture and Forestry Science Hunan Applied Technology University  Changde Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hunan University of Arts and Science  Changde Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hunan University of Arts and Science  Changde Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lan Lei","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hunan University of Arts and Science  Changde Hunan 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