{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:22Z","timestamp":1789992742440,"version":"4.0.1"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016293","name":"University of Mazandaran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016293","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polymeric nanocarriers represent a promising drug delivery platform for neurological disorders. This study evaluated the neuroprotective effects of gallic acid\u2010loaded carrageenan nanoparticles (GA\u2010CG NPs) in a rat model of global cerebral ischemia\/reperfusion (I\/R) injury. Rats were randomly assigned to four groups, including Control, I\/R, GA (free gallic acid), and GA\u2010CG NPs. GA and GA\u2010CG NPs were administered orally for 14\u2009days before I\/R induction. Following I\/R, depressive\u2010like behaviors and cognitive function, cerebral infarct volume, activities of antioxidant enzymes (SOD, CAT, GPx), glutathione (GSH), dopamine (DA) levels, and lipid peroxidation (MDA) were evaluated. GA\u2010CG NPs pretreatment significantly improved behavioral disorders and reduced infarct volume compared to the I\/R group. The nanoparticle formulation enhanced antioxidant defenses, increasing SOD, CAT, GPx, GSH, and DA levels while decreasing MDA. Notably, GA\u2010CG NPs demonstrated superior neuroprotection to free GA across all measured parameters. These findings indicate that GA\u2010CG NPs effectively prevent I\/R\u2010induced oxidative brain damage and may represent a promising therapeutic strategy for cerebral ischemia complications.<\/jats:p>","DOI":"10.1002\/fsn3.71751","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:36:05Z","timestamp":1777455365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive Effect of Gallic Acid\u2010Loaded Carrageenan Nanoparticles Against Cerebral Ischemia\/Reperfusion Injury in Rat: Modulation of Oxidative Pathway"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0843-8440","authenticated-orcid":false,"given":"Akbar","family":"Hajizadeh Moghaddam","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Science University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Jahani Bahnamiri","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Khanjani Jelodar","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Fendereski Jaz","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Nasiriansari","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Hasantabar","sequence":"additional","affiliation":[{"name":"Department of Organic Polymer Chemistry, Faculty of Chemistry University of Mazandaran  Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176670"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2018.07.012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747\u20104949.2009.00387.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.11.014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110985"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00735-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(76)90527\u20103"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.09.023"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647\u2010200101000\u201000002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121263"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051131"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.12.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1762353"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.04.012"},{"key":"e_1_2_12_17_1","first-page":"407","volume-title":"Methods in Enzymology","author":"Esterbauer H.","year":"1990"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010022\u201000579\u20101"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113353"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.01.003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/521349"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.22.405"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016103131408"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.04.018"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.25.1451"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157765"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114606"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118349"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201005050\u2010w"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104977"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100262"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241305899"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104773"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2017.01.041"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.11.063"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.11.022"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2020.06.011"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173066"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13111744"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2012.738437"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.779330"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.97592"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100478"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190425190754"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4073.588"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113284"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.12.049"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.07.005"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2020.1753769"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238\u2010016\u20100307\u20100"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.5.2.155"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2018.04.006"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00028"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.186"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114068"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.020"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204613"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010023\u201008771\u20100"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.04.014"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.04.009"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1630358"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2019.2230"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:37:58Z","timestamp":1789990678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/fsn3.71751"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71751","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71751"}}