{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:29Z","timestamp":1790172449993,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["RS\u20102022\u2010RD010228"],"award-info":[{"award-number":["RS\u20102022\u2010RD010228"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Artemisia argyi<\/jats:italic>\n                    (Pyeong\u2010an\u2010ae) has long been used in traditional medicine for gynecological conditions; however, its efficacy in treating premenstrual syndrome (PMS) remains underexplored. This study investigated the effects of\n                    <jats:italic>A. argyi<\/jats:italic>\n                    extracts on prolactin secretion, prostaglandin regulation, and inflammatory responses associated with PMS. Extracts were prepared using water and ethanol at various temperatures and screened in estradiol\u2010stimulated GH3 cells. Notably, a 95\u00b0C water extract and 50\u00b0C 50% ethanol extract significantly suppressed prolactin secretion and modulated PGE1 and PGE2 levels without exhibiting cytotoxicity. These two extracts were further evaluated in a mouse model of metoclopramide\u2010induced hyperprolactinemia. The water extract significantly reduced prolactin levels; restored estradiol, follicle\u2010stimulating hormone, and luteinizing hormone concentrations; and improved uterine and inflammatory markers, comparable to the effects of bromocriptine treatment. Additionally,\n                    <jats:italic>A. argyi<\/jats:italic>\n                    extracts altered prostaglandin balance and decreased interleukin (IL)\u20101\u03b2 and IL\u20106 expression in uterine tissue. These findings suggest that\n                    <jats:italic>A. argyi<\/jats:italic>\n                    , particularly its water extract, may provide a promising natural therapeutic option for managing PMS symptoms through endocrine and inflammatory regulation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71764","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:10:12Z","timestamp":1775797812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Artemisia argyi<\/i>\n                    Extracts Modulate Prolactin and Prostaglandin Pathways in Estrogen\u2010Stimulated\n                    <scp>GH3<\/scp>\n                    Cells and a Hyperprolactinemia Mouse Model"],"prefix":"10.1002","volume":"14","author":[{"given":"Min\u2010Jung","family":"Ma","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural &amp; Herbal Science, RDA  Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeWan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural &amp; Herbal Science, RDA  Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongkyun","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural &amp; Herbal Science, RDA  Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Food Science R&amp;D Center, Kolmar BNH CO., Ltd.  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