{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:06:25Z","timestamp":1790172385764,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Agrimonia pilosa<\/jats:italic>\n                    Ledeb. (APL) is an edible and medicinal plant, which has a favorable cardioprotective effect. Myocardial fibrosis (MF) is a hallmark pathological feature of various cardiovascular diseases. This study aims to evaluate its protective effects against isoproterenol (ISO)\u2010induced MF and investigate the underlying mechanisms. HPLC was employed to analyze the main active ingredients in APL. Network pharmacology methods, combined with experimental validation, elucidated the mechanism by which APL modulates mitophagy to alleviate MF. HPLC analysis showed that six ingredients\u00a0were identified. We demonstrated that APL significantly attenuated myocardial injury, enhanced cardiac function, inhibited oxidative stress and apoptosis, and effectively ameliorated MF progression. Network pharmacological predictions and in\u00a0vivo experimental validation demonstrated that APL exerts its therapeutic effects through regulation of the FOXO signaling pathway and suppression of excessive mitophagy. Furthermore, we artificially elevated FOXO1 expression in\u00a0vitro, which reversed the effects of APL, as evidenced by increased expression of mitophagy and fibrosis\u2010related proteins. Consistent results from both in\u00a0vivo and in\u00a0vitro experiments demonstrated that APL attenuates ISO\u2010induced MF and suppresses mitophagy mediated by the FOXO signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71778","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:59:57Z","timestamp":1776304797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of\n                    <scp>\n                      <i>Agrimonia pilosa<\/i>\n                    <\/scp>\n                    Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the\n                    <scp>FOXO<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei International Joint Research Center of Chinese Medicine Resource Utilization and Quality Evaluation  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei International Joint Research Center of Chinese Medicine Resource Utilization and Quality Evaluation  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"An","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei International Joint Research Center of Chinese Medicine Resource Utilization and Quality Evaluation  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dantong","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei International Joint Research Center of Chinese Medicine Resource Utilization and Quality Evaluation  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei International Joint Research Center of Chinese Medicine Resource Utilization and Quality Evaluation  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei 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