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The limited conventional nutritional strategies in conferring long\u2010term thermotolerance underscore the urgent need for innovative and biologically effective interventions. In this context, phytobiotics, bioactive plant\u2010derived compounds, have emerged as promising nutrigenomic modulators due to their potent antioxidant, anti\u2010inflammatory, antimicrobial, and gut\u2010protective properties, which collectively reinforce cellular defense mechanisms and enhance physiological adaptability under thermal challenge. This review provides a novel nutrigenomic perspective by elucidating how phytobiotics regulate the expression of key stress\u2010responsive molecular pathways, including heat shock proteins (HSPs), nuclear factor erythroid 2\u2013related factor 2 (Nrf2), nuclear factor kappa B (NF\u2010\u03baB), and mitogen\u2010activated protein kinases (MAPKs), which govern oxidative balance, immune signaling, and apoptosis. Importantly, these mechanistic insights are reinforced by emerging in silico approaches, such as molecular docking and network pharmacology, which offer predictive validation of phytobiotic bioactivity, binding affinities, and target specificity against stress\u2010related biomarkers, thereby accelerating the identification of high\u2010potential candidates. By integrating experimental and computational evidence, this review consolidates current knowledge on the genomic and physiological roles of phytobiotics in mitigating HS and associated pathophysiological disturbances, and provides an effective scientific framework for the development of sustainable, phytobiotic\u2010based nutritional strategies to enhance resilience and productivity in climate\u2010vulnerable animal production systems.<\/jats:p>","DOI":"10.1002\/fsn3.71788","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:46:49Z","timestamp":1776314809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species\u2013An In Silico Supported Review"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Chongqing Three Gorges Vocational College  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Chongqing Three Gorges Vocational College  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-8175","authenticated-orcid":false,"given":"Muhammad Asif","family":"Arain","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture, Water and Marine Sciences  Uthal Balochistan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al\u2010Rasheed","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences, University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2023.105057"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vas.2025.100487"},{"issue":"9","key":"e_1_2_15_4_1","first-page":"1073","article-title":"Impacts of Dietary Humic Acid Supplementation on Growth Performance, Some Blood Metabolites and Carcass Traits of Broiler Chicks","volume":"86","author":"Abd El\u2010Hack M. 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