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In recent years, bioactive peptides have attracted increasing attention as promising hypoglycaemic candidates due to their favorable safety profiles, good tolerability, and multi\u2010target physiological regulatory activities. As a GRAS\u2010designated unicellular green alga,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Chlamydomonas reinhardtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    is characterized by a high protein content, with approximately 46.9% of its dry biomass composed of protein, making it a rich source for the development of hypoglycaemic short peptides. Previous studies have shown that proteolytic products derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. reinhardtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    markedly inhibit key glucose\u2010regulating enzymes, including \u03b1\u2010amylase and \u03b1\u2010glucosidase, exhibiting superior inhibitory potential compared with various terrestrial protein sources. Nevertheless, challenges remain in the large\u2010scale production of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. reinhardtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010derived hypoglycaemic peptides, precise control of the proteolytic process, and validation of their in\u00a0vivo efficacy. This review summarizes the major sources of hypoglycaemic peptides, current extraction and characterization strategies, and their underlying mechanisms of action, while highlighting the application potential and key limitations of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. reinhardtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010derived hypoglycaemic peptides. Addressing these challenges is expected to facilitate the development and application of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. reinhardtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010based functional foods and nutraceuticals for diabetes management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71790","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:29:56Z","timestamp":1776227396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms and Production of Hypoglycaemic Peptides: Exploring the Potential of\n                    <i>Chlamydomonas reinhardtii<\/i>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1104-1816","authenticated-orcid":false,"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"School 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