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This study examined the phenolic composition, the antioxidant activity, and the anticancer effects of methanolic, ethanolic, and aqueous extracts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. australis<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. The in\u00a0vitro cytotoxic efficacy was assessed with the MTT assay on six tumor cell lines (HeLa, MV4\u201011, OCI\u2010AML3, DAOY, OSN\u201076, and U\u2010138\u2010MG) and two non\u2010cancerous cell lines (HEK293T and hCMEC\/D3).\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. australis<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. extracts exhibited moderate antioxidant activity, as evidenced by their high IC\n                    <jats:sub>50<\/jats:sub>\n                    values (110\u2013436\u2009\u03bcg\/mL). The FRAP reducing power was low (2.09\u20136.24\u2009mg AAE\/g), and the aqueous extract was least active, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 152 to 207\u2009\u03bcg\/mL in the ABTS assay. The HPLC\u2010ESI\u2010MS\/MS analysis indicated that the extracts contain a variety of phenolic compounds dominated by neochlorogenic acid, chlorogenic acid, procyanidin B2, (\u2212)\u2010epicatechin, isoquercitrin, rutin, phloretin, and delphindin\u20103,5\u2010diglucoside. Cytotoxicity assays demonstrated a dose\u2010dependent reduction in cell viability, with DAOY cells exhibiting the highest sensitivity. Water extract exhibited significant inhibitory effects at elevated concentrations, whereas ethanol extract showed greater potency at intermediate doses (7.5%\u201350%) for specific cancer cell lines. Methanol extract exhibited a more gradual impact and showed reduced potency at elevated doses. According to IC\n                    <jats:sub>50<\/jats:sub>\n                    values, the ethanolic extract was the most efficacious in four out of the six cancer cell lines, whereas water extract demonstrated notable potency for OCI\u2010AML3 and OSN\u201076 but were less effective on normal cells, suggesting selectivity based on cell type. The selectivity index indicated that methanol exhibited the highest selectivity, especially against OSN\u201076, MV4\u201011, OCI\u2010AML3, and HeLa cell lines, implying its predilection for cancer cells over normal cells. Ethanol demonstrated notable selectivity, particularly toward OSN\u201076 and MV4\u201011. Conversely, water extracts exhibited minimal selectivity across all strains. In summary, methanol and ethanol extracts demonstrate the best potential for selective anticancer efficacy.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71800","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:40:04Z","timestamp":1776660004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenolic Diversity, Antioxidant Activity, and Anticancer Potential of\n                    <i>Celtis australis<\/i>\n                    L. Fruits: New Insights"],"prefix":"10.1002","volume":"14","author":[{"given":"Jihane","family":"Touhtouh","sequence":"first","affiliation":[{"name":"Laboratory of Natural Resources and Environment, Polydisciplinary Faculty of Taza Sidi Mohamed Ben Abdellah University of Fez  Taza Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Aanniz","sequence":"additional","affiliation":[{"name":"Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical and Pharmacy School Mohammed V University  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-1631","authenticated-orcid":false,"given":"Abdelhakim","family":"Bouyahya","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences Mohammed V University in Rabat  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Acquaticci","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chemistry Interdisciplinary Project (ChIP) University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Namazzadeh","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chemistry Interdisciplinary Project (ChIP) University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-877X","authenticated-orcid":false,"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chemistry Interdisciplinary Project (ChIP) University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2984-9262","authenticated-orcid":false,"given":"Waleed","family":"Al Abdulmonem","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alorini","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-2818","authenticated-orcid":false,"given":"Taoufiq","family":"Benali","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Environment, Polydisciplinary Faculty of Taza Sidi Mohamed Ben Abdellah University of Fez  Taza Morocco"},{"name":"Laboratory of Ecotoxicology, Bioresources, and Coastal Geomorphology, Polydisciplinary Faculty of Safi Cadi Ayyad University  Safi Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Hammani","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Environment, Polydisciplinary Faculty of Taza Sidi Mohamed Ben Abdellah University of Fez  Taza Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Abbouyi A. 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