{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:13:19Z","timestamp":1789992799799,"version":"4.0.1"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO. 82505032"],"award-info":[{"award-number":["NO. 82505032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cyperi Rhizoma (CR), a globally invasive weed threatening major crops, paradoxically represents an underutilized resource for sustainable nutraceutical development. In order to transform this agricultural pest into a viable functional food ingredient, this review explores how culinary\u2010inspired processing (vinegar, wine, salt, etc.) and food\u2010compatible botanical pairings synergistically enhance the bioactivity of CR. We demonstrate that traditional processing deglycosylates flavonoids and modulates volatile oils, boosting bioavailability and analgesic, antidepressant efficacy validated in\u00a0vivo. Herb pairs with food\u2010medicines generate novel metabolites and amplify bioactivity, as exemplified by the CR\u2010Alpiniae Officinarum Rhizoma herb pair that promotes gastric ulcer inhibition via gut barrier repair. Moreover, CR\u2010based formulations show clinical success in digestive\/neurological disorders. This work connects weed control strategies with value\u2010added food uses, including spice blends and nanoparticle\u2010encapsulated supplements, establishing the scientific basis for transforming CR into scalable, culturally adapted functional foods. These innovations target global health needs while reducing agricultural damage caused by this invasive plant.<\/jats:p>","DOI":"10.1002\/fsn3.71808","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:02:14Z","timestamp":1778853734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the Bioactivity of Cyperi Rhizoma as a Functional Food: Insights From Culinary Processing and Herb Combinations"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuehan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"},{"name":"Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education  Chengdu Sichuan China"},{"name":"Lab for Innovation &amp; Effective Uses of Chinese Drug Germplasm Resources  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"},{"name":"Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education  Chengdu Sichuan China"},{"name":"Lab for Innovation &amp; Effective Uses of Chinese Drug Germplasm Resources  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"},{"name":"Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education  Chengdu Sichuan China"},{"name":"Lab for Innovation &amp; Effective Uses of Chinese Drug Germplasm Resources  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu Sichuan China"},{"name":"Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education  Chengdu Sichuan China"},{"name":"Lab for Innovation &amp; Effective Uses of Chinese Drug Germplasm Resources  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6451-0582","authenticated-orcid":false,"given":"Tianhui","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"23","key":"e_1_2_10_2_1","first-page":"305","article-title":"Progress in Research on Secondary Metabolites and Biological Activity of Medicinal and Edible Citrus Plants","volume":"43","author":"Cao X. 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