{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:01:56Z","timestamp":1790164916446,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2026R69"],"award-info":[{"award-number":["PNURSP2026R69"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Date fruits (\n                    <jats:italic>Phoenix dactilyfera<\/jats:italic>\n                    L.) are widely produced with huge wasted by\u2010products (seeds\/pits and fibers) in remarkable nutritional and economic potential value. This study aims to examine the impact of the functional properties of date seeds on health status and gut microbiota (GM) modulation in diabetic rats. Collected samples were dried and used in powdered form (DSP) for chemical compositions. Diabetic rats were then fed with this (5%, 10%, and 15%) versus control healthy group. Blood samples were used for glucose (BG) with lipid profiles (cholesterol; CHO), triglycerides (TG), high\u2010density lipoprotein (HDL) and low\u2010density lipoprotein (LDL). Additionally, kidney (Urea, Criatinine) and histological function and GM were measured. Data indicated that DSP contain crude fiber, total sugar, and crude fat about 77%, 6%, and 6% respectively. Additionally, potassium was the highest while phosphorus shows the lowest (31.53\u2009\u00b1\u20091.19 vs. 2.48\u2009\u00b1 0.31\u2009g\/100\u2009g DSP). Iron, calcium, sodium, and magnesium were 14.29\u2009\u00b1\u20090.59, 12.53\u2009\u00b1\u20090.49, 9.23\u2009\u00b1\u20090.22, and 7.60\u2009\u00b1\u20090.42\u2009g\/100\u2009g DSP respectively. The 10% and 15% DSP supplementations affected the GM;\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Clostridium histolyticum<\/jats:italic>\n                    <\/jats:styled-content>\n                    reductions versus\n                    <jats:italic>Bifidobacteria, Lactobacillus<\/jats:italic>\n                    enhancement. Also, kidney functions and lipid profile improved especially at 15% supplementations (CHO and TG decrease vs. HDL\u2010c increase). Valorization of date seed by\u2010products indicates their potential health effects on lipids and kidney functions among diabetic models influenced by their antioxidant, mineral and fiber levels in association to GM composition. However, further studies are needed on humans with sustainable utilization manner of food waste.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71841","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:01:36Z","timestamp":1777874496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Functional Potential of Date (\n                    <i>Phoenix dactylifera<\/i>\n                    ) Seed Bioactives in Modulating Gut Microbiota in Diabetic Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9711-0269","authenticated-orcid":false,"given":"Nouf Abdullah","family":"Alharbi","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences, College of Applied Medical Sciences Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-9208","authenticated-orcid":false,"given":"Saleh A.","family":"Alsanie","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, College of Applied Medical Sciences Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-5155","authenticated-orcid":false,"given":"Asmahan A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, College of Agriculture and Food Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aeshah","family":"Alhosain","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, College of Agriculture and Food Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-8115","authenticated-orcid":false,"given":"Tarfa","family":"Albrahim","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Nutrition, College of Health and Rehabilitation Sciences Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-0422","authenticated-orcid":false,"given":"Thamer","family":"Aljutaily","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, College of Agriculture and Food Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-5528","authenticated-orcid":false,"given":"Huda","family":"Aljumayi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Sciences Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-0795","authenticated-orcid":false,"given":"Isam A.","family":"Mohamed Ahmed","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agricultural Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0602-8263","authenticated-orcid":false,"given":"Belal M.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agricultural Sciences King Saud University  Riyadh Saudi Arabia"},{"name":"Department of Food Science and Technology, Faculty of Agriculture and Food Sciences Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-7344","authenticated-orcid":false,"given":"Nazeha A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Nutrition and Food Sciences Department, Faculty of Home Economics Menoufia University  Shibin El Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104543"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179715"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010217"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.24925\/turjaf.v13i1.229\u2010236.7148"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4503"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14245315"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.9755\/ejfa.2023.v35.i1.2963"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.11.4.05"},{"key":"e_1_2_13_10_1","volume-title":"Official Methods of Analysis of the Association of Official Analytical Chemists","author":"AOAC","year":"2000"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1324793"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.30848\/PJB2024\u20103(24)"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010025\u201004075\u20100"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173491"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010020\u201000576\u20106"},{"key":"e_1_2_13_16_1","doi-asserted-by":"crossref","unstructured":"FAO.2023.\u201cWorld Food and Agriculture\u2014Statistical Yearbook 2023.\u201dhttps:\/\/doi.org\/10.4060\/cc8166en.","DOI":"10.4060\/cc8166en"},{"key":"e_1_2_13_17_1","first-page":"491","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Prebiotics","volume":"14","author":"Gibson G. R.","year":"2017","journal-title":"Medical Biochemistry Communications"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01611-z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112022"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.21608\/mjmr.2023.184444.1271"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2024.101354"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2020.100409"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/fst.95222"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3946"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.101149"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2013.825700"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmic.2025.100144"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387\u2010024\u201000287\u20101"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717\u201095022020000401003"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2022.100951"},{"key":"e_1_2_13_31_1","article-title":"Potential Health Effects of Tomato (\n                     Lycopersicon esculentum\n                  ) Juice and Hypoglycemic Amelioration in the Atherogenic Indices Between Diabetic Animal Models","volume":"42","author":"Nazeha K.","year":"2023","journal-title":"Food Science and Technology"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11062499"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.06.024"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.834485"}],"updated-by":[{"DOI":"10.1002\/fsn3.72407","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000}}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:35:58Z","timestamp":1789990558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/fsn3.71841"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71841","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71841"}}