{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:47Z","timestamp":1791216467660,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This investigation reports the effects of\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    CQPC03 (LP\u2010CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan\u2010induced mouse thrombosis model. High\u2010throughput 16S rRNA sequencing determined the composition of intestinal microorganisms. Biochemical reagents, section observations, and quantitative polymerase chain reaction (qPCR) identified mouse serum and tissue\u2010related markers. Experimental findings show that LP\u2010CQPC03 enhances activated partial thromboplastin time (APTT) and decreases thrombin time (TT), fibrinogen (FIB), and prothrombin time (PT). LP\u2010CQPC03 also significantly reduces black tail severity in thrombotic mice. Moreover, LP\u2010CQPC03 lowers malondialdehyde (MDA), tumor necrosis factor alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), nuclear factor kappa\u2010B (NF\u2010\u03baB), and interleukin\u20101 beta (IL\u20101\u03b2) levels in thrombotic mouse serum, while increasing superoxide dismutase (SOD) and catalase (CAT) activities. Hematoxylin and eosin (H&amp;E) pathological analysis reveals that LP\u2010CQPC03 lessens tissue damage caused by tail vein thrombosis. In the colon tissues of thrombotic mice, LP\u2010CQPC03 up\u2010regulates the mRNA expression of copper\/zinc superoxide dismutase (Cu\/Zn\u2010SOD), manganese superoxide dismutase (Mn\u2010SOD), and CAT, while down\u2010regulating NF\u2010\u03baB p65, IL\u20106, TNF\u2010\u03b1, and interferon gamma (IFN\u2010\u03b3). In tail vein vascular tissues, LP\u2010CQPC03 also suppresses the mRNA expression of NF\u2010\u03baB p65, intercellular cell adhesion molecule\u20101 (ICAM\u20101), vascular cell adhesion molecule\u20101 (VCAM\u20101), and E\u2010selectin. Gut microbiota sequencing results show that LP\u2010CQPC03 increases the population of beneficial bacteria and decreases harmful ones. These findings demonstrate that LP\u2010CQPC03 prevents thrombosis in mice, reduces oxidative stress and intestinal inflammation, and regulates gut microbiota by increasing beneficial bacteria. A high concentration of LP\u2010CQPC03 shows a better effect, comparable to heparin.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71842","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:56:42Z","timestamp":1777701402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Lactiplantibacillus plantarum<\/i>\n                    CQPC03 Reduces Carrageenan\u2010Induced Thrombosis in Mice via Controlling the Flora in the Gut"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-7865","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Child Nutrition and Health Development, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Chongqing Seventh People's Hospital  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong Port Land\u2010Sea (Jinan) Hotel Management Co. 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