{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:04Z","timestamp":1789992724345,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505032"],"award-info":[{"award-number":["82505032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cyperus rotundus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. (CR), a globally pervasive weed with dual agricultural and medicinal significance, undergoes vinegar\u2010processed (VCR) to enhance its hepatoprotective properties. This study investigated the phytochemical and functional changes induced by vinegar processing and elucidated the role of \u03b1\u2010cyperone, a key bioactive sesquiterpene, in modulating gut\u2010liver axis homeostasis. UPLC\u2010Q\u2010Exactive Orbitrap MS and HPLC analyses revealed a significant increase in \u03b1\u2010cyperone content post\u2010vinegar processing. In thioacetamide\u2010induced acute and chronic liver injury models, VCR significantly outperformed CR in reducing serum ALT and AST, hepatic TNF\u2010\u03b1 and IL\u20106, and oxidative stress, while restoring gut barrier integrity via up\u2010regulation of ZO\u20101 and occludin. Molecular docking supported \u03b1\u2010cyperone's high\u2010affinity binding to the TLR4\/NF\u2010\u03baB pathway, corroborated by western blot and immunofluorescence. Gut microbiota analysis demonstrated VCR's capacity to reverse dysbiosis, notably enriching Bacteroidetes and improving microbial diversity. These findings highlight edible vinegar processing as a sustainable strategy to transform agricultural waste into a functional food\u2010grade intervention for liver health, mediated by \u03b1\u2010cyperone\u2010driven modulation of the gut\u2010liver axis.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71850","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:42:31Z","timestamp":1777959751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the Hepatoprotective Potential of\n                    <i>Cyperus rotundus<\/i>\n                    Through Edible Vinegar Processing: A Study on Functional Ingredient Enhancement"],"prefix":"10.1002","volume":"14","author":[{"given":"Gao","family":"Jia\u2010He","sequence":"first","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li\u2010Ting","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine; Key Laboratory of Standardization of Chinese Medicine (Chengdu University of Traditional Chinese Medicine), Ministry of Education; Lab for Innovation &amp; Effective Uses of Chinese Drug Germplasm Resources  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yue\u2010Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Fu\u2010Chao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Jun\u2010Tong","sequence":"additional","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6451-0582","authenticated-orcid":false,"given":"Gao","family":"Tian\u2010Hui","sequence":"additional","affiliation":[{"name":"School of Pharmacy Qilu Medical University  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12434"},{"key":"e_1_2_12_4_1","first-page":"343","article-title":"Determination of \u03b1\u2010Cyperone Content in Different Processed Products of Rhizoma Cyperi","volume":"21","author":"Chen S.","year":"1999","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO03052J"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109324"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1081\/PFC-200034257"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2010.05.020"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.03.004"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154090"},{"key":"e_1_2_12_12_1","first-page":"133","article-title":"Synergistic Mechanism of Curcuma Phaeocaulis Genuine Regional Materia Medicafrom Sichuan Province Processing With Vinegar to Invade Liver via \u201cGut\u2010Liver Axis\u201d","volume":"56","author":"Gao T. 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