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Although its therapeutic potential in gastric health has been widely acknowledged, the underlying mechanisms by which it modulates the gut microbiota and affects metabolic profiles in the context of gastric diseases remain incompletely understood. On the basis of the \u201cgut microbiota and metabolites\u201d regulatory network, this study elucidated the mechanism of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. erinaceus<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (HEE) in alleviating ethanol\u2010induced acute gastric injury. The results showed that HEE alleviated ethanol\u2010induced acute gastric injury, downregulated 12 (S)\u2010HETE, and enriched short\u2010chain fatty acid (SCFA)\u2010producing bacteria. Notably, the water extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. erinaceus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (WEHE) additionally elevated propionic acid. These SCFA\u2010producing bacteria were positively correlated with propionic acid but negatively correlated with 12 (S)\u2010HETE. These results suggest that WEHE may enhance the protective effect on the stomach by regulating the \u201cgut microbiota\u2010metabolites\u201d axis.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71851","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:01:03Z","timestamp":1778482863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Hericium erinaceus<\/i>\n                    Extracts Exert Gastroprotective Effects Through Modulation of the Gut Microbiota and Metabolites"],"prefix":"10.1002","volume":"14","author":[{"given":"Ruixin","family":"Bei","sequence":"first","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"},{"name":"Zhejiang International Joint Laboratory of Traditional Medicine and Big Health Products Development  Hangzhou 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