{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:04Z","timestamp":1789992724277,"version":"4.0.1"},"reference-count":87,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Lannea coromandelica<\/jats:italic>\n                    (Anacardiaceae) has been traditionally used in Ayurvedic medicine to treat various ailments. However, its pharmacological potential remains largely unverified. This study investigates the methanolic fruit extract of\n                    <jats:italic>L. coromandelica<\/jats:italic>\n                    (ME) through in\u00a0vitro, in\u00a0vivo, in silico, and GC\u2013MS analyses to validate its traditional uses. The extract was assessed for its total phenolic and flavonoid content, and phytoconstituents were identified using GC\u2013MS profiling. Antioxidant activity was measured by DPPH and ABTS assays, while cytotoxicity was evaluated using brine shrimp lethality and HeLa cell viability assays. Antidiabetic activity was assessed by \u03b1\u2010amylase inhibition, antibacterial properties were tested by agar well diffusion, and anti\u2010inflammatory and sedative effects were evaluated in Swiss albino mice using carrageenan\u2010induced paw edema and behavioral tests. Molecular docking studies targeted SUR\u20101, DNA gyrase B, caspase\u20103, COX\u20102, and the GABA\u2010A receptor. ME exhibited significant phenolic (35\u2009\u00b1\u20091.03\u2009mg\/g) and flavonoid (11.57\u2009\u00b1\u20090.37\u2009mg\/g) content, with GC\u2013MS analysis identifying phenolics, terpenoids, and fatty acid derivatives. The extract demonstrated strong antioxidant (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 31.49 and 48.94\u2009\u03bcg\/mL), cytotoxic (LC\n                    <jats:sub>50<\/jats:sub>\n                    : 36.22\u2009\u03bcg\/mL; &lt;\u20095% HeLa survival), and \u03b1\u2010amylase inhibitory (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 93.09\u2009\u03bcg\/mL) activities. It also showed broad\u2010spectrum antibacterial effects, excellent anti\u2010inflammatory activity, and significant sedative effects (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Molecular docking revealed strong ligand\u2010target interactions. These results support the pharmacological potential of ME, validating its traditional uses and suggesting its promise for developing therapies targeting inflammation, infection, metabolic, and neurological diseases. Further preclinical and clinical studies are recommended.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71858","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:01:32Z","timestamp":1778043692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological Evaluation of Methanolic Fruit Extract of\n                    <i>Lannea coromandelica<\/i>\n                    : Antioxidant, Cytotoxic, Antidiabetic, Antibacterial, Anti\u2010Inflammatory, and Sedative Activities"],"prefix":"10.1002","volume":"14","author":[{"given":"Priota Islam","family":"Meem","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5157-9298","authenticated-orcid":false,"given":"Zobayed","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-1520","authenticated-orcid":false,"given":"Nazmul Hasan","family":"Eshaque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram Murad","family":"Mojidee","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Chemical Engineering University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Badrudduja","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Chemical Engineering University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Dam","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-3257","authenticated-orcid":false,"given":"S. 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