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This study evaluated the hepatoprotective effects of an edible ultra\u2010micro powder\u2014formulated from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pueraria lobata<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cornus officinalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cistanche deserticola<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:italic>Dendrobium officinale<\/jats:italic>\n                    \u2014against alcohol\u2010induced damage in mice. Mice were randomly assigned to seven groups: Normal, Alcohol, Silymarin, KingDrink, and ultra\u2010micro powder (low, medium, and high doses) for 1\u2009week of daily treatment. The medium dose (1\u2009g\/kg) was most effective, reducing serum aspartate aminotransferase and triglyceride levels, lowering hepatic malondialdehyde, and maintaining liver architecture with minimal microvesicular steatosis. The powder increased alcohol dehydrogenase, acetaldehyde dehydrogenase, and superoxide dismutase activities, thereby enhancing alcohol metabolism and antioxidant defense. Additionally, it suppressed TLR4\/NF\u2010\u03baB and NLRP3\/ASC signaling, indicating an anti\u2010inflammatory mechanism. 16S rRNA sequencing revealed gut microbiota modulation, specifically reducing Proteobacteria and Escherichia\u2010Shigella while enriching Lactobacillus. Correlation analysis linked Verrucomicrobiota and Lactobacillus to improved liver function. Collectively, this powder exerts hepatoprotection through antioxidant, anti\u2010inflammatory, and microbiota\u2010modulating actions, highlighting its potential as a functional food for preventing alcoholic liver injury.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71890","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:24:51Z","timestamp":1778736291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultra\u2010Micro Powder From Edible Plants (\n                    <i>Pueraria lobata<\/i>\n                    ,\n                    <i>Cornus officinalis<\/i>\n                    ,\n                    <i>Cistanche deserticola<\/i>\n                    , and\n                    <i>Dendrobium officinale<\/i>\n                    ) Reshapes Intestinal Flora and Attenuates Liver Injury in Alcohol\u2010Induced Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Jia\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Xiamen Medicine Research Institute  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-8607","authenticated-orcid":false,"given":"Li\u2010Tao","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University  Xiamen Fujian China"},{"name":"Institute of Pharmaceutical Engineering Huaqiao University  Xiamen Fujian China"},{"name":"Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154199"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"377","article-title":"Pathogenesis of Alcoholic Fatty Liver Disease: Molecular and Cellular Changes","volume":"47","author":"Azahar S. 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