{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:01Z","timestamp":1789992721790,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010051","name":"Guizhou Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["[2024]08"],"award-info":[{"award-number":["[2024]08"]}],"id":[{"id":"10.13039\/501100010051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Oxalis corniculata<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. is a well\u2010known herb valued for its dual edible and medicinal properties, with its acidic compounds endowing food with a distinct flavor and enhancing its value. This study identified the active compounds in its ethanol extract (OCEE) and clarified the molecular mechanisms underlying its fracture\u2010healing effects. UHPLC\u2010Q\u2010Exactive\u2010MS\/MS was used for comprehensive chemical profiling of OCEE, and network pharmacology was applied to explore therapeutic targets and signaling pathways related to fracture treatment. Molecular docking (MD), molecular dynamics simulations (MDS), and in\u00a0vitro cell assays further validated the core mechanisms. A total of 549 compounds were identified in OCEE, with naringenin\u20107\u2010O\u2010glucuronide, chrysophanol\u20108\u2010O\u2010glucoside, and 2\u2010oxo\u20103\u2010phenylpropanoic acid as key potential active components. These compounds targeted GAPDH, TNF, TP53, and other core proteins, which are involved in nitrogen metabolism, IL\u201017 signaling, and arachidonic acid metabolism pathways critical for fracture healing. MD and MDS confirmed strong binding affinities between key compounds and core targets, and qPCR results revealed that OCEE significantly upregulated the expression of TNF\u03b1, MMP9, and ESR1 while downregulating TP53 expression in\u00a0vitro. These findings clarify the material basis and molecular pathways of OCEE in promoting fracture healing and provide experimental evidence for its application as a functional food and natural agent for bone health and fracture recovery.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71896","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:33:42Z","timestamp":1779190422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>Oxalis corniculata<\/i>\n                    <\/scp>\n                    L. Ethanol Extract Promotes Fracture Healing: Integrated Omics and Experimental Validation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9797-725X","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Life Sciences and Agri\u2010Forestry Southwest University of Science and Technology  Mianyang China"},{"name":"GuiZhou Institute of Subtropical Crops Guizhou Academy of Agricultural Sciences  Guiyang China"},{"name":"Engineering Research Center of Biomass Materials, Ministry of Education Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wangcang County Hospital of Traditional Chinese Medicine  Guangyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Long","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Agri\u2010Forestry Southwest University of Science and Technology  Mianyang China"},{"name":"Engineering Research Center of Biomass Materials, Ministry of Education Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Agri\u2010Forestry Southwest University of Science and Technology  Mianyang China"},{"name":"Engineering Research Center of Biomass Materials, Ministry of Education Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Agri\u2010Forestry Southwest University of Science and Technology  Mianyang China"},{"name":"Engineering Research Center of Biomass Materials, Ministry of Education Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyan","family":"Shen","sequence":"additional","affiliation":[{"name":"Research and Development Department Guizhou Weikang Zifan Pharmaceutical co., Ltd.  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112266"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.11.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2013.804039"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.164"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjag053"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"},{"key":"e_1_2_11_9_1","volume-title":"Quality Standards of Traditional Chinese Medicine and Ethnic Medicine in Guizhou Province","author":"Guizhou Medical Products Administration","year":"2003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.11.017"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083922"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae112"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.3230"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116977"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0261\u20105614(97)80034\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22711"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18275"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3085"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136651"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102836(84)90231\u20106"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758\u20102946\u20106\u201013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.000000000000038"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112854"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.05.024"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726\u2010021\u201002959\u2010z"},{"issue":"2","key":"e_1_2_11_26_1","first-page":"147","article-title":"Hepatoprotective Activity of \n                     Oxalis corniculata\n                   L. 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