{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:12:22Z","timestamp":1789992742423,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Miao Sour Soup (MSS) is a traditional fermented dish containing bioactive constituents such as lycopene, capsaicin, and short\u2010chain fatty acids, which have been associated with anti\u2010obesity, anti\u2010inflammatory, and antioxidant effects. Excessively elevated hepatic gluconeogenesis is a critical element instigating energy metabolism dysregulation in the body. This research examined the extent to which MSS enhances energy metabolism abnormalities caused by a high\u2010fat diet via hepatic gluconeogenesis and confirmed this route. The findings indicated that MSS intervention markedly decreased hepatic lipid accumulation, pro\u2010inflammatory cytokine secretion, and blood lipid and glucose levels in rats subjected to a high\u2010fat diet. Non\u2010targeted metabolomics study revealed that MSS influences energy metabolism pathways, including glycolysis and gluconeogenesis. Subsequently, Western blot analysis was conducted to assess protein expression in the NF\u2010\u03baB inflammatory pathway and the PI3K\/Akt\/Foxo1 signaling pathway. The findings indicated that MSS decreased NF\u2010\u03baB expression in the livers of rats subjected to a high\u2010fat diet, thereby activating the PI3K\/Akt\/Foxo1 signaling pathway and decreasing the expression of PEPCK and G6PC, essential proteins in gluconeogenesis. This study's results demonstrate that Foxo1 is a crucial protein in the dysregulation of glucose metabolism caused by lipid metabolism diseases. MSS may stimulate the PI3K\/Akt\/Foxo1 signaling pathway by mitigating chronic inflammation caused by a high\u2010fat diet, therefore inhibiting excessive hepatic gluconeogenesis and ultimately improving insulin resistance.<\/jats:p>","DOI":"10.1002\/fsn3.71900","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:25:37Z","timestamp":1779341137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Miao Sour Soup Modulates Hepatic Gluconeogenesis Through PI3K\/Akt\/Foxo1 Signaling in High\u2010Fat Diet\u2013Induced Rats"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0395-5959","authenticated-orcid":false,"given":"Xue","family":"Ao","sequence":"first","affiliation":[{"name":"School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education Guizhou Medical University  Guiyang 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