{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:11:42Z","timestamp":1789992702597,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017590","name":"Hubei University of Science and Technology","doi-asserted-by":"publisher","award":["Q201810"],"award-info":[{"award-number":["Q201810"]}],"id":[{"id":"10.13039\/501100017590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017590","name":"Hubei University of Science and Technology","doi-asserted-by":"publisher","award":["BK202332"],"award-info":[{"award-number":["BK202332"]}],"id":[{"id":"10.13039\/501100017590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017590","name":"Hubei University of Science and Technology","doi-asserted-by":"publisher","award":["2022TNB06"],"award-info":[{"award-number":["2022TNB06"]}],"id":[{"id":"10.13039\/501100017590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["24058"],"award-info":[{"award-number":["24058"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity and metabolic dysfunction associated steatotic liver disease (MASLD) are interrelated metabolic disorders characterized by chronic inflammation, insulin resistance, and dyslipidemia. While both conditions are well recognized clinically, the molecular mechanisms underlying their frequent coexistence remain poorly understood. Growing evidence indicates that circulatory exosomal microRNAs (miRNAs) act as critical mediators of inter\u2010organ communication. In this PROSPERO\u2010registered systematic review (CRD420251017335), we integrated clinical evidence with bioinformatics analyses to clarify shared miRNA\u2010mediated regulatory networks between obesity and MASLD. Literature was retrieved from MEDLINE, ISI Web of Science, and Embase. Bioinformatics analysis using miRWalk also revealed shared miRNAs, predicted target genes, and elucidated enriched pathways using Gene Ontology and KEGG. Clinical studies identified 93 obesity\u2010associated and 24 MASLD\u2010associated exosomal miRNAs, with\n                    <jats:italic>let\u20107b<\/jats:italic>\n                    and\n                    <jats:italic>miR\u2010335\u20105p<\/jats:italic>\n                    emerging as common nodes. Bioinformatics analysis using miRWalk revealed extensive overlap at the functional level, including 40,410 shared miRNA\u2010mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals, including\n                    <jats:italic>miR\u2010122<\/jats:italic>\n                    ,\n                    <jats:italic>miR\u2010192<\/jats:italic>\n                    ,\n                    <jats:italic>miR\u2010128<\/jats:italic>\n                    , and\n                    <jats:italic>miR\u20109\u20105p<\/jats:italic>\n                    , were consistently associated with liver histopathology, inflammatory markers, and liver enzyme levels. Importantly, obesity\u2010derived\n                    <jats:italic>miR\u2010298<\/jats:italic>\n                    ,\n                    <jats:italic>miR\u2010342<\/jats:italic>\n                    , and\n                    <jats:italic>let\u20107d\u20105p<\/jats:italic>\n                    showed strong diagnostic performance (AUC \u2265\u20090.85), exceeding that of alanine aminotransferase (ALT). Furthermore,\n                    <jats:italic>ADIPOQ<\/jats:italic>\n                    emerged as a central therapeutic target within the shared miRNA network, regulated by both\n                    <jats:italic>let\u20107b<\/jats:italic>\n                    and\n                    <jats:italic>miR\u2010335\u20105p<\/jats:italic>\n                    , providing a molecular link between adipose tissue dysfunction and hepatic metabolic regulation. This integrative analysis supports a unified model in which exosomal miRNAs serve as key molecular intermediaries connecting obesity and MASLD.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71901","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:52:19Z","timestamp":1779436339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Consolidating Clinical Insights and Uncovering Novel Regulatory Mechanisms of Exosomal MicroRNAs in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease: A Systematic Review and Bioinformatics Analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Qigui","family":"Mo","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Xianning Medical College Hubei University of Science and Technology  Xianning P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirreza","family":"Ghafourian","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Alidadipour","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Davoudi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Miao","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Xianning Medical College Hubei University of Science and Technology  Xianning P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-118X","authenticated-orcid":false,"given":"Reza","family":"Afrisham","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molood","family":"Bagherieh","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences  Ramsar Iran"},{"name":"Department of Biochemistry and Genetics, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115665240285539240214111947"},{"issue":"5","key":"e_1_2_14_3_1","article-title":"Epigenetic Regulation of Thyroid Hormone Action in Human Metabolic Dysfuntion\u2010Associated Steatohepatitis","volume":"13","author":"Alison\u2010Michelle Naujack C. 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